THE EFFECT OF THE POLYMORPHISM OF THE INTERLEUKIN-28 GENE ON THE EFFECTIVENESS OF THE ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIC EPSTEIN-BARR VIRUS INFECTION
Among many factors that directly affect the immune system, herpes viruses deserve special attention. Currently, Epstein-Barr virus (VEB) is recognized as an etiological agent of not only infectious mononucleosis, limphoadenopathy syndrome, but also oncological processes such as nasopharyngeal carcin...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Poltava State Medical University
2017-11-01
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| Series: | Проблеми екології та медицини |
| Subjects: | |
| Online Access: | https://ecomed-journal.org/index.php/journal/article/view/72 |
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| Summary: | Among many factors that directly affect the immune system, herpes viruses deserve special attention. Currently, Epstein-Barr virus (VEB) is recognized as an etiological agent of not only infectious mononucleosis, limphoadenopathy syndrome, but also oncological processes such as nasopharyngeal carcinoma, Burkitt lymphoma, T- and B-cell lymphoma in HIV-infected people. The aim of this work was to study the effect of the polymorphism of the interleukin-28 gene on the effectiveness of the antiviral therapy in patients with chronic VEB-infection. We examined 92 patients with chronic forms of the VEB: 38 patients (41.3%) had genotypes CC (locus rs12979860 IL-28B); 32 patients (34.7%) with the CT genotype; 22 patients (23.9%) with the TT genotype. As a result of this work, it was found that in patients with chronic VEB-infection who had the genotype CC and CT, the high effectiveness of antiviral therapy is much more often noted. Given the high effectiveness of valacyclovir in these patient groups, it is advisable to further recommend patients to adhere to the treatment regimen used. In patients with the TT genotype, in most cases had low effectiveness of antiviral therapy and it is possible to think that to improve the effectiveness of therapy of such patients it is necessary to supplement the used treatment with immunomodulating medications. |
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| ISSN: | 2073-4662 2519-2302 |