Redox‐Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3‐Mediated NRF2 Deubiquitination

Redox‐Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3‐Mediated NRF2 Deubiquitination

Abstract Inflammatory bowel disease (IBD) is associated with oxidative stress and redox signaling disruption. It is recently reported that proautophagic autophagy/beclin‐1 regulator 1 (AMBRA1) is a positive modulator of the NF‐κB pathway that promotes intestinal inflammation. However, its effect on...

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Bibliographic Details
Main Authors: Weimin Xu, Zhebin Hua, Yaosheng Wang, Wenbo Tang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Yubei Gu, Chen‐Ying Liu, Peng Du
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
AMBRA1
inflammatory bowel disease
intestinal oxidative stress
NRF2
USP7
Online Access:https://doi.org/10.1002/advs.202411320
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