The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review
Chronic pain is considered an economic burden on society as it often results in disability, job loss, and early retirement. Opioids are the most common analgesics prescribed for the management of moderate to severe pain. However, chronic exposure to these drugs can result in opioid tolerance and opi...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/6682275 |
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| author | Xia-qing Wang Tahmineh Mokhtari Yu-xuan Zeng Lu-peng Yue Li Hu |
| author_facet | Xia-qing Wang Tahmineh Mokhtari Yu-xuan Zeng Lu-peng Yue Li Hu |
| author_sort | Xia-qing Wang |
| collection | DOAJ |
| description | Chronic pain is considered an economic burden on society as it often results in disability, job loss, and early retirement. Opioids are the most common analgesics prescribed for the management of moderate to severe pain. However, chronic exposure to these drugs can result in opioid tolerance and opioid-induced hyperalgesia. On pain modulation strategies, exploiting the multitarget drugs with the ability of the superadditive or synergistic interactions attracts more attention. In the present report, we have reviewed the analgesic effects of different dopamine receptors, particularly D1 and D2 receptors, in different regions of the central nervous system, including the spinal cord, striatum, nucleus accumbens (NAc), and periaqueductal gray (PAG). According to the evidence, these regions are not only involved in pain modulation but also express a high density of DA receptors. The findings can be categorized as follows: (1) D2-like receptors may exert a higher analgesic potency, but D1-like receptors act in different manners across several mechanisms in the mentioned regions; (2) in the spinal cord and striatum, antinociception of DA is mainly mediated by D2-like receptors, while in the NAc and PAG, both D1- and D2-like receptors are involved as analgesic targets; and (3) D2-like receptor agonists can act as adjuvants of μ-opioid receptor agonists to potentiate analgesic effects and provide a better approach to pain relief. |
| format | Article |
| id | doaj-art-012666c39bf84d118f0d26f88fb6db20 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-012666c39bf84d118f0d26f88fb6db202025-02-03T01:24:38ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/66822756682275The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative ReviewXia-qing Wang0Tahmineh Mokhtari1Yu-xuan Zeng2Lu-peng Yue3Li Hu4CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, ChinaCAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, ChinaCAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, ChinaCAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, ChinaCAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, ChinaChronic pain is considered an economic burden on society as it often results in disability, job loss, and early retirement. Opioids are the most common analgesics prescribed for the management of moderate to severe pain. However, chronic exposure to these drugs can result in opioid tolerance and opioid-induced hyperalgesia. On pain modulation strategies, exploiting the multitarget drugs with the ability of the superadditive or synergistic interactions attracts more attention. In the present report, we have reviewed the analgesic effects of different dopamine receptors, particularly D1 and D2 receptors, in different regions of the central nervous system, including the spinal cord, striatum, nucleus accumbens (NAc), and periaqueductal gray (PAG). According to the evidence, these regions are not only involved in pain modulation but also express a high density of DA receptors. The findings can be categorized as follows: (1) D2-like receptors may exert a higher analgesic potency, but D1-like receptors act in different manners across several mechanisms in the mentioned regions; (2) in the spinal cord and striatum, antinociception of DA is mainly mediated by D2-like receptors, while in the NAc and PAG, both D1- and D2-like receptors are involved as analgesic targets; and (3) D2-like receptor agonists can act as adjuvants of μ-opioid receptor agonists to potentiate analgesic effects and provide a better approach to pain relief.http://dx.doi.org/10.1155/2021/6682275 |
| spellingShingle | Xia-qing Wang Tahmineh Mokhtari Yu-xuan Zeng Lu-peng Yue Li Hu The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review Neural Plasticity |
| title | The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review |
| title_full | The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review |
| title_fullStr | The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review |
| title_full_unstemmed | The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review |
| title_short | The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review |
| title_sort | distinct functions of dopaminergic receptors on pain modulation a narrative review |
| url | http://dx.doi.org/10.1155/2021/6682275 |
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