Synthesis of β-Cyclodextrin-Functionalized Silver Nanoparticles and Their Application for Loading Cytisine and Its Phosphorus Derivative
In this study, the synthesis and properties of β-cyclodextrin-functionalized silver nanoparticles and their loading with a drug component are considered. β-Cyclodextrin was used as a reducing agent and stabilizer in the preparation of silver nanoparticles. The use of β-CD-AgNPs in loading molecules...
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2025-03-01
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| author | Serik D. Fazylov Oralgazy A. Nurkenov Zhangeldy S. Nurmaganbetov Akmaral Zh. Sarsenbekova Ryszhan Ye. Bakirova Olzhas T. Seilkhanov Alexandr K. Sviderskiy Ardak K. Syzdykov Anel Zh. Mendibayeva |
| author_facet | Serik D. Fazylov Oralgazy A. Nurkenov Zhangeldy S. Nurmaganbetov Akmaral Zh. Sarsenbekova Ryszhan Ye. Bakirova Olzhas T. Seilkhanov Alexandr K. Sviderskiy Ardak K. Syzdykov Anel Zh. Mendibayeva |
| author_sort | Serik D. Fazylov |
| collection | DOAJ |
| description | In this study, the synthesis and properties of β-cyclodextrin-functionalized silver nanoparticles and their loading with a drug component are considered. β-Cyclodextrin was used as a reducing agent and stabilizer in the preparation of silver nanoparticles. The use of β-CD-AgNPs in loading molecules of the alkaloid cytisine (Cz) and its O,O-dimethyl-N-cytisinilphosphate (CzP) derivative, which have pronounced antiviral properties, was studied. The formation of β-CD-Cz-AgNPs and β-CD-CzP-AgNPs was confirmed by UV spectroscopy and X-ray diffraction spectroscopy. Scanning electron microscopy and transmission electron microscopy showed that the obtained β-CD-Cz-AgNP and β-CD-CzP-AgNP nanocomposites were well dispersed with particle sizes in the range of 3–20 nm. <sup>1</sup>H-, <sup>13</sup>C-NMR and COSY, HMQC, HMBC and Fourier transform infrared spectroscopy revealed the reduction and encapsulation of AgNPs by β-Cz, and the TEM imaging results showed an increase in the size of nanoparticles after the introduction of cytisine and its phosphorus derivative. The kinetic parameters of the thermal degradation process of β-CD, Cz, CzP and their inclusion complexes Cz(CzP)-β-CD-AgNPs under isothermal conditions, which ensure the preservation of the kinetic triplet, were determined. The differences in the mechanism of thermal decomposition of the studied materials are described by the parameters of the Šesták–Berggren model (m and n), which demonstrated differences for different compounds: for β-CD, the values of the parameters m and n are 0.47 and 0.53, respectively, while for CzP-β-CD-AgNPs they reach values of 0.66 and 1.34. These results indicate differences in the mechanism of thermal decomposition of the studied materials. |
| format | Article |
| id | doaj-art-0125f6517ded4de2b6b3bd33c2a6f6c2 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-0125f6517ded4de2b6b3bd33c2a6f6c22025-08-20T03:43:34ZengMDPI AGMolecules1420-30492025-03-01306133710.3390/molecules30061337Synthesis of β-Cyclodextrin-Functionalized Silver Nanoparticles and Their Application for Loading Cytisine and Its Phosphorus DerivativeSerik D. Fazylov0Oralgazy A. Nurkenov1Zhangeldy S. Nurmaganbetov2Akmaral Zh. Sarsenbekova3Ryszhan Ye. Bakirova4Olzhas T. Seilkhanov5Alexandr K. Sviderskiy6Ardak K. Syzdykov7Anel Zh. Mendibayeva8Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, KazakhstanInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, KazakhstanInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, KazakhstanDepartment of Physical and Analytical Chemistry, Karaganda University of the Name of E.A. Buketov, Karaganda 100074, KazakhstanDepartment of Internal Diseases, Karaganda Medical University, Karaganda 100012, KazakhstanLaboratory of Engineering Profile NMR-Spectroscopy, Sh. Ualikhanov Kokshetau University, Kokshetau 120000, KazakhstanDepartment of Mining, Metallurgy and Natural Sciences, Zhezkazgan University of the Name of O. Baikonurov, Zhezkazgan 100600, KazakhstanInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, KazakhstanInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, KazakhstanIn this study, the synthesis and properties of β-cyclodextrin-functionalized silver nanoparticles and their loading with a drug component are considered. β-Cyclodextrin was used as a reducing agent and stabilizer in the preparation of silver nanoparticles. The use of β-CD-AgNPs in loading molecules of the alkaloid cytisine (Cz) and its O,O-dimethyl-N-cytisinilphosphate (CzP) derivative, which have pronounced antiviral properties, was studied. The formation of β-CD-Cz-AgNPs and β-CD-CzP-AgNPs was confirmed by UV spectroscopy and X-ray diffraction spectroscopy. Scanning electron microscopy and transmission electron microscopy showed that the obtained β-CD-Cz-AgNP and β-CD-CzP-AgNP nanocomposites were well dispersed with particle sizes in the range of 3–20 nm. <sup>1</sup>H-, <sup>13</sup>C-NMR and COSY, HMQC, HMBC and Fourier transform infrared spectroscopy revealed the reduction and encapsulation of AgNPs by β-Cz, and the TEM imaging results showed an increase in the size of nanoparticles after the introduction of cytisine and its phosphorus derivative. The kinetic parameters of the thermal degradation process of β-CD, Cz, CzP and their inclusion complexes Cz(CzP)-β-CD-AgNPs under isothermal conditions, which ensure the preservation of the kinetic triplet, were determined. The differences in the mechanism of thermal decomposition of the studied materials are described by the parameters of the Šesták–Berggren model (m and n), which demonstrated differences for different compounds: for β-CD, the values of the parameters m and n are 0.47 and 0.53, respectively, while for CzP-β-CD-AgNPs they reach values of 0.66 and 1.34. These results indicate differences in the mechanism of thermal decomposition of the studied materials.https://www.mdpi.com/1420-3049/30/6/1337silver nanoparticlescytisineantiviral activityβ-cyclodextrininclusion complexsilver nanoparticles |
| spellingShingle | Serik D. Fazylov Oralgazy A. Nurkenov Zhangeldy S. Nurmaganbetov Akmaral Zh. Sarsenbekova Ryszhan Ye. Bakirova Olzhas T. Seilkhanov Alexandr K. Sviderskiy Ardak K. Syzdykov Anel Zh. Mendibayeva Synthesis of β-Cyclodextrin-Functionalized Silver Nanoparticles and Their Application for Loading Cytisine and Its Phosphorus Derivative Molecules silver nanoparticles cytisine antiviral activity β-cyclodextrin inclusion complex silver nanoparticles |
| title | Synthesis of β-Cyclodextrin-Functionalized Silver Nanoparticles and Their Application for Loading Cytisine and Its Phosphorus Derivative |
| title_full | Synthesis of β-Cyclodextrin-Functionalized Silver Nanoparticles and Their Application for Loading Cytisine and Its Phosphorus Derivative |
| title_fullStr | Synthesis of β-Cyclodextrin-Functionalized Silver Nanoparticles and Their Application for Loading Cytisine and Its Phosphorus Derivative |
| title_full_unstemmed | Synthesis of β-Cyclodextrin-Functionalized Silver Nanoparticles and Their Application for Loading Cytisine and Its Phosphorus Derivative |
| title_short | Synthesis of β-Cyclodextrin-Functionalized Silver Nanoparticles and Their Application for Loading Cytisine and Its Phosphorus Derivative |
| title_sort | synthesis of β cyclodextrin functionalized silver nanoparticles and their application for loading cytisine and its phosphorus derivative |
| topic | silver nanoparticles cytisine antiviral activity β-cyclodextrin inclusion complex silver nanoparticles |
| url | https://www.mdpi.com/1420-3049/30/6/1337 |
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