Prolonged Honeymoon Phase in Adult-Onset Type 1 Diabetes Mellitus: A Case Study
Abstract Type 1 diabetes mellitus (T1DM) exhibits heterogeneity in presentation, and the “honeymoon” period, characterized by temporary beta-cell function restoration, is a significant aspect influencing disease progression. Adult-onset T1DM differs from pediatric cases, with complete insulin withdr...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Journal of Diabetology |
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| Online Access: | https://doi.org/10.4103/jod.jod_31_24 |
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| author | Pranjali Shah |
| author_facet | Pranjali Shah |
| author_sort | Pranjali Shah |
| collection | DOAJ |
| description | Abstract Type 1 diabetes mellitus (T1DM) exhibits heterogeneity in presentation, and the “honeymoon” period, characterized by temporary beta-cell function restoration, is a significant aspect influencing disease progression. Adult-onset T1DM differs from pediatric cases, with complete insulin withdrawal being rare. This study investigates a 23-year-old female positive for glutamic acid decarboxylase (GAD) antibodies to assess the potential for an extended honeymoon phase. The patient, without significant medical history, presented with recurrent boils, notable weight loss, and had a family history of diabetes (maternal grandmother). Laboratory results showed uncontrolled hyperglycemia, absence of C-peptide, and positive for anti-GAD. Treatment involved CGMS fixation and insulin degludec/aspart, leading to excellent sugar control. Notably, insulin dosage reduction and improved C-peptide levels occurred over two years. This case highlights the complexity of T1DM presentations, the potential for extended honeymoon phases, and emphasizes the need for personalized management. Ongoing research into honeymoon phase determinants and genetic aspects will refine the understanding and optimize care for autoimmune diabetes. |
| format | Article |
| id | doaj-art-0125ae22098f4b44bb801bdd382fdf16 |
| institution | Kabale University |
| issn | 2078-7685 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Diabetology |
| spelling | doaj-art-0125ae22098f4b44bb801bdd382fdf162025-01-25T10:15:27ZengWolters Kluwer Medknow PublicationsJournal of Diabetology2078-76852024-04-0115223824010.4103/jod.jod_31_24Prolonged Honeymoon Phase in Adult-Onset Type 1 Diabetes Mellitus: A Case StudyPranjali ShahAbstract Type 1 diabetes mellitus (T1DM) exhibits heterogeneity in presentation, and the “honeymoon” period, characterized by temporary beta-cell function restoration, is a significant aspect influencing disease progression. Adult-onset T1DM differs from pediatric cases, with complete insulin withdrawal being rare. This study investigates a 23-year-old female positive for glutamic acid decarboxylase (GAD) antibodies to assess the potential for an extended honeymoon phase. The patient, without significant medical history, presented with recurrent boils, notable weight loss, and had a family history of diabetes (maternal grandmother). Laboratory results showed uncontrolled hyperglycemia, absence of C-peptide, and positive for anti-GAD. Treatment involved CGMS fixation and insulin degludec/aspart, leading to excellent sugar control. Notably, insulin dosage reduction and improved C-peptide levels occurred over two years. This case highlights the complexity of T1DM presentations, the potential for extended honeymoon phases, and emphasizes the need for personalized management. Ongoing research into honeymoon phase determinants and genetic aspects will refine the understanding and optimize care for autoimmune diabetes.https://doi.org/10.4103/jod.jod_31_24autoimmune diabetesbeta-cell functiongad antibodiesgenetic testinghoneymoon phaseinsulin managementpersonalized caretype 1 diabetes mellitus |
| spellingShingle | Pranjali Shah Prolonged Honeymoon Phase in Adult-Onset Type 1 Diabetes Mellitus: A Case Study Journal of Diabetology autoimmune diabetes beta-cell function gad antibodies genetic testing honeymoon phase insulin management personalized care type 1 diabetes mellitus |
| title | Prolonged Honeymoon Phase in Adult-Onset Type 1 Diabetes Mellitus: A Case Study |
| title_full | Prolonged Honeymoon Phase in Adult-Onset Type 1 Diabetes Mellitus: A Case Study |
| title_fullStr | Prolonged Honeymoon Phase in Adult-Onset Type 1 Diabetes Mellitus: A Case Study |
| title_full_unstemmed | Prolonged Honeymoon Phase in Adult-Onset Type 1 Diabetes Mellitus: A Case Study |
| title_short | Prolonged Honeymoon Phase in Adult-Onset Type 1 Diabetes Mellitus: A Case Study |
| title_sort | prolonged honeymoon phase in adult onset type 1 diabetes mellitus a case study |
| topic | autoimmune diabetes beta-cell function gad antibodies genetic testing honeymoon phase insulin management personalized care type 1 diabetes mellitus |
| url | https://doi.org/10.4103/jod.jod_31_24 |
| work_keys_str_mv | AT pranjalishah prolongedhoneymoonphaseinadultonsettype1diabetesmellitusacasestudy |