Protamine 2 deficiency results in Septin 12 abnormalities

Protamine 2 deficiency results in Septin 12 abnormalities

There is a well-established link between abnormal sperm chromatin states and poor motility, however, how these two processes are interdependent is unknown. Here, we identified a possible mechanistic insight by showing that Protamine 2, a nuclear DNA packaging protein in sperm, directly interacts wit...

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Main Authors: Ondrej Sanovec, Michaela Frolikova, Veronika Kraus, Jana Vondrakova, Maryam Qasemi, Daniela Spevakova, Ondrej Simonik, Lindsay Moritz, Drew Lewis Caswell, Frantisek Liska, Lukas Ded, Jiri Cerny, Tomer Avidor-Reiss, Saher Sue Hammoud, Hubert Schorle, Pavla Postlerova, Klaus Steger, Katerina Komrskova
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Protamine 2 deficiency
Septin 12
sperm
asthenozoospermia
sperm immotility
annulus
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1447630/full
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