Epithelial Downgrowth after Intraocular Surgery Treated with Intracameral 5-Fluorouracil
Purpose. To present the clinical and histopathologic correlation of two cases of epithelial downgrowth (EDG) after prior intraocular surgery. Methods. Observational case reports. Results. We present two cases of EDG occurring after intraocular surgery. In both cases, after two anterior chamber injec...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Ophthalmological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/325485 |
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| author | Nina Ni Marc A. Goldberg Ralph C. Eagle Christopher J. Rapuano Julia A. Haller |
| author_facet | Nina Ni Marc A. Goldberg Ralph C. Eagle Christopher J. Rapuano Julia A. Haller |
| author_sort | Nina Ni |
| collection | DOAJ |
| description | Purpose. To present the clinical and histopathologic correlation of two cases of epithelial downgrowth (EDG) after prior intraocular surgery. Methods. Observational case reports. Results. We present two cases of EDG occurring after intraocular surgery. In both cases, after two anterior chamber injections of 5-fluorouracil (5FU), the area of EDG initially regressed. In Case 1, a limited area of EDG eventually recurred, and penetrating keratoplasty with cryotherapy was curative. In Case 2, subsequent corneal edema required Descemet-stripping automated endothelial keratoplasty, and the patient remained clinically free of EDG without further treatment. Conclusion. Intracameral 5FU may have a role in the treatment of EDG after intraocular surgery, though its precise utilization and impact remain to be defined. |
| format | Article |
| id | doaj-art-011eee19973349bdb32b5baec660a59a |
| institution | OA Journals |
| issn | 2090-6722 2090-6730 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Ophthalmological Medicine |
| spelling | doaj-art-011eee19973349bdb32b5baec660a59a2025-08-20T02:03:13ZengWileyCase Reports in Ophthalmological Medicine2090-67222090-67302015-01-01201510.1155/2015/325485325485Epithelial Downgrowth after Intraocular Surgery Treated with Intracameral 5-FluorouracilNina Ni0Marc A. Goldberg1Ralph C. Eagle2Christopher J. Rapuano3Julia A. Haller4Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USAThe Eye Institute, Tulsa, OK, USAWills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USAWills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USAWills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USAPurpose. To present the clinical and histopathologic correlation of two cases of epithelial downgrowth (EDG) after prior intraocular surgery. Methods. Observational case reports. Results. We present two cases of EDG occurring after intraocular surgery. In both cases, after two anterior chamber injections of 5-fluorouracil (5FU), the area of EDG initially regressed. In Case 1, a limited area of EDG eventually recurred, and penetrating keratoplasty with cryotherapy was curative. In Case 2, subsequent corneal edema required Descemet-stripping automated endothelial keratoplasty, and the patient remained clinically free of EDG without further treatment. Conclusion. Intracameral 5FU may have a role in the treatment of EDG after intraocular surgery, though its precise utilization and impact remain to be defined.http://dx.doi.org/10.1155/2015/325485 |
| spellingShingle | Nina Ni Marc A. Goldberg Ralph C. Eagle Christopher J. Rapuano Julia A. Haller Epithelial Downgrowth after Intraocular Surgery Treated with Intracameral 5-Fluorouracil Case Reports in Ophthalmological Medicine |
| title | Epithelial Downgrowth after Intraocular Surgery Treated with Intracameral 5-Fluorouracil |
| title_full | Epithelial Downgrowth after Intraocular Surgery Treated with Intracameral 5-Fluorouracil |
| title_fullStr | Epithelial Downgrowth after Intraocular Surgery Treated with Intracameral 5-Fluorouracil |
| title_full_unstemmed | Epithelial Downgrowth after Intraocular Surgery Treated with Intracameral 5-Fluorouracil |
| title_short | Epithelial Downgrowth after Intraocular Surgery Treated with Intracameral 5-Fluorouracil |
| title_sort | epithelial downgrowth after intraocular surgery treated with intracameral 5 fluorouracil |
| url | http://dx.doi.org/10.1155/2015/325485 |
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