Non-coding RNAs as key players in neurodegeneration and brain tumors: Insights into therapeutic strategies
Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and other ncRNA types, have emerged as key regulators in neurodegenerative diseases and brain tumors. This review aims to provide insights into the role of ncRNAs in these conditions and their potential as diagno...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2025-08-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_26103_9096fb66a1be731b309c3726cd07f64f.pdf |
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| author | Mohamed Javad Saadh Sarraa Ahmad Qahtan Rafid Jihad Albadr Gaurav Sanghvi Rangaswamy Roopashree Aditya Kashyap A. Sabarivani Jasur Rizaev Waam Mohammed Taher Mariem Alwan Mahmod Jasem Jawad Ali M. Ali Al-Nuaimi |
| author_facet | Mohamed Javad Saadh Sarraa Ahmad Qahtan Rafid Jihad Albadr Gaurav Sanghvi Rangaswamy Roopashree Aditya Kashyap A. Sabarivani Jasur Rizaev Waam Mohammed Taher Mariem Alwan Mahmod Jasem Jawad Ali M. Ali Al-Nuaimi |
| author_sort | Mohamed Javad Saadh |
| collection | DOAJ |
| description | Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and other ncRNA types, have emerged as key regulators in neurodegenerative diseases and brain tumors. This review aims to provide insights into the role of ncRNAs in these conditions and their potential as diagnostic and therapeutic targets. We systematically reviewed literature from databases such as PubMed, Scopus, and Web of Science, applying specific inclusion and exclusion criteria to ensure comprehensive coverage of recent advancements. Although ncRNAs are involved in a range of molecular pathways, challenges in clinical translation, including specificity, cost, and validation, persist. This review highlights innovative strategies to overcome these barriers and promote the clinical application of ncRNAs. Moreover, we explore the emerging role of extracellular vesicle-enriched ncRNAs as cell-free therapeutic options for neurodegenerative diseases. The findings presented here emphasize the need for robust validation and the development of specific ncRNA-based treatments. |
| format | Article |
| id | doaj-art-0116850eda6c49dfbc44e63a974a0b3d |
| institution | DOAJ |
| issn | 2008-3866 2008-3874 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj-art-0116850eda6c49dfbc44e63a974a0b3d2025-08-20T03:08:33ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742025-08-0128896298510.22038/ijbms.2025.85350.1844626103Non-coding RNAs as key players in neurodegeneration and brain tumors: Insights into therapeutic strategiesMohamed Javad Saadh0Sarraa Ahmad Qahtan1Rafid Jihad Albadr2Gaurav Sanghvi3Rangaswamy Roopashree4Aditya Kashyap5A. Sabarivani6Jasur Rizaev7Waam Mohammed Taher8Mariem Alwan9Mahmod Jasem Jawad10Ali M. Ali Al-Nuaimi11Faculty of Pharmacy, Middle East University, Amman, 11831, JordanDepartment of Anesthesia Techniques, Health and Medical Techniques College, Alnoor University, Mosul, IraqAhl al Bayt University, Karbala, IraqMarwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi University, Rajkot-360003, Gujarat, IndiaDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, IndiaCentre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, IndiaDepartment of Biomedical, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, IndiaDepartment of Public Health and Healthcare Management, Rector, Samarkand State Medical University, 18, Amir Temur Street, Samarkand, UzbekistanCollege of Nursing, National University of Science and Technology, Dhi Qar, IraqPharmacy college, Al-Farahidi University, IraqDepartment of Pharmacy, Al-Zahrawi University College, Karbala, IraqGilgamesh Ahliya University, Baghdad, IraqNon-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and other ncRNA types, have emerged as key regulators in neurodegenerative diseases and brain tumors. This review aims to provide insights into the role of ncRNAs in these conditions and their potential as diagnostic and therapeutic targets. We systematically reviewed literature from databases such as PubMed, Scopus, and Web of Science, applying specific inclusion and exclusion criteria to ensure comprehensive coverage of recent advancements. Although ncRNAs are involved in a range of molecular pathways, challenges in clinical translation, including specificity, cost, and validation, persist. This review highlights innovative strategies to overcome these barriers and promote the clinical application of ncRNAs. Moreover, we explore the emerging role of extracellular vesicle-enriched ncRNAs as cell-free therapeutic options for neurodegenerative diseases. The findings presented here emphasize the need for robust validation and the development of specific ncRNA-based treatments.https://ijbms.mums.ac.ir/article_26103_9096fb66a1be731b309c3726cd07f64f.pdfalzheimer’s diseasebrain cancerextracellular vesicles gliomalong non-coding rnamicrorna neurodegenerative diseasesnon-coding rna |
| spellingShingle | Mohamed Javad Saadh Sarraa Ahmad Qahtan Rafid Jihad Albadr Gaurav Sanghvi Rangaswamy Roopashree Aditya Kashyap A. Sabarivani Jasur Rizaev Waam Mohammed Taher Mariem Alwan Mahmod Jasem Jawad Ali M. Ali Al-Nuaimi Non-coding RNAs as key players in neurodegeneration and brain tumors: Insights into therapeutic strategies Iranian Journal of Basic Medical Sciences alzheimer’s disease brain cancer extracellular vesicles glioma long non-coding rna microrna neurodegenerative diseases non-coding rna |
| title | Non-coding RNAs as key players in neurodegeneration and brain tumors: Insights into therapeutic strategies |
| title_full | Non-coding RNAs as key players in neurodegeneration and brain tumors: Insights into therapeutic strategies |
| title_fullStr | Non-coding RNAs as key players in neurodegeneration and brain tumors: Insights into therapeutic strategies |
| title_full_unstemmed | Non-coding RNAs as key players in neurodegeneration and brain tumors: Insights into therapeutic strategies |
| title_short | Non-coding RNAs as key players in neurodegeneration and brain tumors: Insights into therapeutic strategies |
| title_sort | non coding rnas as key players in neurodegeneration and brain tumors insights into therapeutic strategies |
| topic | alzheimer’s disease brain cancer extracellular vesicles glioma long non-coding rna microrna neurodegenerative diseases non-coding rna |
| url | https://ijbms.mums.ac.ir/article_26103_9096fb66a1be731b309c3726cd07f64f.pdf |
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