Acute generalized exanthematous pustulosis induced by ceftriaxone with positive patch testing
Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous reaction. In over 90% of patients it is an adverse reaction to drugs. Delayed-type (type IV) hypersensitivity seems to play an important role in its pathophysiology. Positive patch tests have ranged from 18% to 75%, with 93...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2024-02-01
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| Series: | Alergologia Polska |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Acute-generalized-exanthematous-pustulosis-induced-by-ceftriaxone-with-positive-patch-testing,123,52419,1,1.html |
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| Summary: | Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous reaction. In over 90% of patients it is an adverse reaction to drugs. Delayed-type (type IV) hypersensitivity seems to play an important role in its pathophysiology. Positive patch tests have ranged from 18% to 75%, with 93 culprit drugs identified. Our case involves an 87-year-old female patient, treated for a periprosthetic joint infection with ceftriaxone and daptomycin, who developed acute generalized exanthematous pustulosis. Clinical diagnosis was confirmed by skin biopsy. Patch testing performed five months later confirmed sensitization to ceftriaxone. Patch testing is useful to identify the cause of AGEP when the responsible drug is unclear. |
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| ISSN: | 2353-3854 2391-6052 |