Analysis of the Porphyrin Peak Shift and Fluorescence Lifetime in Gliomas with Different Tumor Grades, Intratumoral Regions, and Visible Fluorescence Status

Analysis of the Porphyrin Peak Shift and Fluorescence Lifetime in Gliomas with Different Tumor Grades, Intratumoral Regions, and Visible Fluorescence Status

<b>Background:</b> 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence shows high sensitivity in detecting the tumor core of high-grade gliomas (HGG) but poor sensitivity for tissue of low-grade gliomas (LGG) and the margins of HGG. The characteristic emission pea...

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Bibliographic Details
Main Authors: Lisa Irina Körner, David Reichert, Marco Andreana, Angelika Unterhuber, Mikael T. Erkkilae, Jessica Makolli, Barbara Kiesel, Mario Mischkulnig, Thomas Rötzer-Pejrimovsky, Adelheid Wöhrer, Mitchel S. Berger, Rainer Leitgeb, Georg Widhalm
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Diagnostics
Subjects:
protoporphyrin IX
5-ALA
fluorescence lifetime
glioma
intraoperative visualization
Online Access:https://www.mdpi.com/2075-4418/14/23/2651
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