An analysis of the burden of respiratory tract cancers in global, China, the United States and India: findings based on the GBD 2021 database
Abstract Objective This study aimed to assess the burden of respiratory tract cancers in China, the United States, India, and worldwide from 1990 to 2021. Also, forecast the evolution of respiratory tract cancers deaths and DALYs burden during 2022 to 2050. Study design An epidemiological analysis....
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2025-03-01
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| Online Access: | https://doi.org/10.1186/s12889-025-21979-y |
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| author | Xinxin Liu Guoyu Wang Yafei Chen Siyi Ma Bozhen Huang Shanshan Song Luyao Wang Wanqing Wang Min Jiang |
| author_facet | Xinxin Liu Guoyu Wang Yafei Chen Siyi Ma Bozhen Huang Shanshan Song Luyao Wang Wanqing Wang Min Jiang |
| author_sort | Xinxin Liu |
| collection | DOAJ |
| description | Abstract Objective This study aimed to assess the burden of respiratory tract cancers in China, the United States, India, and worldwide from 1990 to 2021. Also, forecast the evolution of respiratory tract cancers deaths and DALYs burden during 2022 to 2050. Study design An epidemiological analysis. Methods Based on the GBD 2021 data, this article analyzed and discussed the trends in burden of respiratory tract cancers in China, the United States, India, and the world from 1990 to 2021. Additionally, the Bayesian Age-Period-Cohort (BAPC) model was used to forecast the evolution of respiratory tract cancers deaths and DALYs burden during 2022 to 2050. Results The ASR-Deaths and ASR-DALYs for laryngeal and TBL cancers decreased globally. The burden of disease for TBL cancer increased in China and India (AAPC: 0.38 and 0.69), especially among Chinese women, while laryngeal cancer declined in India (AAPC: -0.69). In contrast, the burden of disease for both cancers declined substantially in the United States (-1.82 AAPC for laryngeal cancer and − 1.74 AAPC for TBL). A notable gender disparity existed in the burden of respiratory tumors, with males experienced a higher disease burden compared to females. In terms of age, the peak incidence of respiratory tract cancers predominantly occurred among individuals aged 65–74, indicating a clear tendency towards a higher prevalence among this age group. Population growth and ageing were primary factors influencing the mortality burden of larynx cancer, whereas epidemiological shifts in TBL cancer markedly impacted DALYs. The forecasted results for ASR-Deaths and ASR-DALYs worldwide from 2022 to 2050 indicated a decline in the burden of both larynx and TBL cancers. However, the deaths and DALYs of TBL cancer in China will show an upward trend, especially for females. Conclusions The disease burden of respiratory tract cancers is a global health issue that needs attention, and situations vary from country to country, requiring personalized measures. Global strategies must address aging populations and socioeconomic disparities to reduce inequities in high-burden regions. |
| format | Article |
| id | doaj-art-0105a95c6aa44a9bbd9c19b4751c977a |
| institution | DOAJ |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
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| series | BMC Public Health |
| spelling | doaj-art-0105a95c6aa44a9bbd9c19b4751c977a2025-08-20T03:01:45ZengBMCBMC Public Health1471-24582025-03-0125111810.1186/s12889-025-21979-yAn analysis of the burden of respiratory tract cancers in global, China, the United States and India: findings based on the GBD 2021 databaseXinxin Liu0Guoyu Wang1Yafei Chen2Siyi Ma3Bozhen Huang4Shanshan Song5Luyao Wang6Wanqing Wang7Min Jiang8Department of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical UniversityInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical SciencesDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical UniversityAbstract Objective This study aimed to assess the burden of respiratory tract cancers in China, the United States, India, and worldwide from 1990 to 2021. Also, forecast the evolution of respiratory tract cancers deaths and DALYs burden during 2022 to 2050. Study design An epidemiological analysis. Methods Based on the GBD 2021 data, this article analyzed and discussed the trends in burden of respiratory tract cancers in China, the United States, India, and the world from 1990 to 2021. Additionally, the Bayesian Age-Period-Cohort (BAPC) model was used to forecast the evolution of respiratory tract cancers deaths and DALYs burden during 2022 to 2050. Results The ASR-Deaths and ASR-DALYs for laryngeal and TBL cancers decreased globally. The burden of disease for TBL cancer increased in China and India (AAPC: 0.38 and 0.69), especially among Chinese women, while laryngeal cancer declined in India (AAPC: -0.69). In contrast, the burden of disease for both cancers declined substantially in the United States (-1.82 AAPC for laryngeal cancer and − 1.74 AAPC for TBL). A notable gender disparity existed in the burden of respiratory tumors, with males experienced a higher disease burden compared to females. In terms of age, the peak incidence of respiratory tract cancers predominantly occurred among individuals aged 65–74, indicating a clear tendency towards a higher prevalence among this age group. Population growth and ageing were primary factors influencing the mortality burden of larynx cancer, whereas epidemiological shifts in TBL cancer markedly impacted DALYs. The forecasted results for ASR-Deaths and ASR-DALYs worldwide from 2022 to 2050 indicated a decline in the burden of both larynx and TBL cancers. However, the deaths and DALYs of TBL cancer in China will show an upward trend, especially for females. Conclusions The disease burden of respiratory tract cancers is a global health issue that needs attention, and situations vary from country to country, requiring personalized measures. Global strategies must address aging populations and socioeconomic disparities to reduce inequities in high-burden regions.https://doi.org/10.1186/s12889-025-21979-yRespiratory tract cancersDisability-adjusted life-yearsMortalityGlobal epidemiologyProjection |
| spellingShingle | Xinxin Liu Guoyu Wang Yafei Chen Siyi Ma Bozhen Huang Shanshan Song Luyao Wang Wanqing Wang Min Jiang An analysis of the burden of respiratory tract cancers in global, China, the United States and India: findings based on the GBD 2021 database BMC Public Health Respiratory tract cancers Disability-adjusted life-years Mortality Global epidemiology Projection |
| title | An analysis of the burden of respiratory tract cancers in global, China, the United States and India: findings based on the GBD 2021 database |
| title_full | An analysis of the burden of respiratory tract cancers in global, China, the United States and India: findings based on the GBD 2021 database |
| title_fullStr | An analysis of the burden of respiratory tract cancers in global, China, the United States and India: findings based on the GBD 2021 database |
| title_full_unstemmed | An analysis of the burden of respiratory tract cancers in global, China, the United States and India: findings based on the GBD 2021 database |
| title_short | An analysis of the burden of respiratory tract cancers in global, China, the United States and India: findings based on the GBD 2021 database |
| title_sort | analysis of the burden of respiratory tract cancers in global china the united states and india findings based on the gbd 2021 database |
| topic | Respiratory tract cancers Disability-adjusted life-years Mortality Global epidemiology Projection |
| url | https://doi.org/10.1186/s12889-025-21979-y |
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