Curcumin-Loaded Chitosan/Gelatin Composite Sponge for Wound Healing Application
Three composite sponges were made with 10% of curcumin and by using polymers, namely, chitosan and gelatin with various ratios. The chemical structure and morphology were evaluated by FTIR and SEM. These sponges were evaluated for water absorption capacity, antibacterial activity, in vitro drug rele...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2013/106570 |
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| _version_ | 1832556377171558400 |
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| author | Van Cuong Nguyen Van Boi Nguyen Ming-Fa Hsieh |
| author_facet | Van Cuong Nguyen Van Boi Nguyen Ming-Fa Hsieh |
| author_sort | Van Cuong Nguyen |
| collection | DOAJ |
| description | Three composite sponges were made with 10% of curcumin and by using polymers, namely, chitosan and gelatin with various ratios. The chemical structure and morphology were evaluated by FTIR and SEM. These sponges were evaluated for water absorption capacity, antibacterial activity, in vitro drug release, and in vivo wound healing studies by excision wound model using rabbits. The in vivo study presented a greater wound closure in wounds treated with curcumin-composite sponge than those with composite sponge without curcumin and untreated group. These obtained results showed that combination of curcumin, chitosan and gelatin could improve the wound healing activity in comparison to chitosan, and gelatin without curcumin. |
| format | Article |
| id | doaj-art-00ffd085289e4c729cf959ff7d0b16f0 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-00ffd085289e4c729cf959ff7d0b16f02025-02-03T05:45:35ZengWileyInternational Journal of Polymer Science1687-94221687-94302013-01-01201310.1155/2013/106570106570Curcumin-Loaded Chitosan/Gelatin Composite Sponge for Wound Healing ApplicationVan Cuong Nguyen0Van Boi Nguyen1Ming-Fa Hsieh2Department of Chemical Engineering, Industrial University of Ho Chi Minh City, 12 Nguyen Van Bao Street, Go Vap, Ho Chi Minh City 70000, VietnamDepartment of Chemical Engineering, Industrial University of Ho Chi Minh City, 12 Nguyen Van Bao Street, Go Vap, Ho Chi Minh City 70000, VietnamDepartment of Biomedical Engineering, Center for Nanotechnology and Institute of Biomedical Technology, Chung Yuan Christian University, 200 Chung Pei Road, Chungli, 32023 Taoyuan, TaiwanThree composite sponges were made with 10% of curcumin and by using polymers, namely, chitosan and gelatin with various ratios. The chemical structure and morphology were evaluated by FTIR and SEM. These sponges were evaluated for water absorption capacity, antibacterial activity, in vitro drug release, and in vivo wound healing studies by excision wound model using rabbits. The in vivo study presented a greater wound closure in wounds treated with curcumin-composite sponge than those with composite sponge without curcumin and untreated group. These obtained results showed that combination of curcumin, chitosan and gelatin could improve the wound healing activity in comparison to chitosan, and gelatin without curcumin.http://dx.doi.org/10.1155/2013/106570 |
| spellingShingle | Van Cuong Nguyen Van Boi Nguyen Ming-Fa Hsieh Curcumin-Loaded Chitosan/Gelatin Composite Sponge for Wound Healing Application International Journal of Polymer Science |
| title | Curcumin-Loaded Chitosan/Gelatin Composite Sponge for Wound Healing Application |
| title_full | Curcumin-Loaded Chitosan/Gelatin Composite Sponge for Wound Healing Application |
| title_fullStr | Curcumin-Loaded Chitosan/Gelatin Composite Sponge for Wound Healing Application |
| title_full_unstemmed | Curcumin-Loaded Chitosan/Gelatin Composite Sponge for Wound Healing Application |
| title_short | Curcumin-Loaded Chitosan/Gelatin Composite Sponge for Wound Healing Application |
| title_sort | curcumin loaded chitosan gelatin composite sponge for wound healing application |
| url | http://dx.doi.org/10.1155/2013/106570 |
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