Milk intake reduced the prevalence of hypertension by decreasing total arsenic levels in fasting serum in Japanese residents
Background: Exposure to arsenic increases the risk of hypertension. Indeed, a high level of arsenic in human serum, a reliable biomarker of arsenic exposure, was shown to be linked to increased prevalence of hypertension among a study of Japanese residents. However, no beneficial food that decreases...
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Elsevier
2025-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325009261 |
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| author | Tingchao He Yuqi Deng Nobutaka Ohgami Takumi Kagawa Akira Tazaki Akihito Harusato Shoko Ohnuma Hisao Naito Takashi Tamura Kenji Wakai Masashi Kato |
| author_facet | Tingchao He Yuqi Deng Nobutaka Ohgami Takumi Kagawa Akira Tazaki Akihito Harusato Shoko Ohnuma Hisao Naito Takashi Tamura Kenji Wakai Masashi Kato |
| author_sort | Tingchao He |
| collection | DOAJ |
| description | Background: Exposure to arsenic increases the risk of hypertension. Indeed, a high level of arsenic in human serum, a reliable biomarker of arsenic exposure, was shown to be linked to increased prevalence of hypertension among a study of Japanese residents. However, no beneficial food that decreases the risk of arsenic-mediated hypertension has been determined by considering intake scores of multiple foods. Methods: The comprehensive effects of combined beverage intake on the risk of hypertension, mediated by decreased levels of total arsenic in fasting serum, were investigated among the same group of 2706 residents. Results: Our generalized linear regression analysis for each beverage showed significant negative associations of serum arsenic levels with milk and vegetable juice intake scores among 11 beverages. Weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) analyses of combined beverage intake scores reveal that milk was the beverage most strongly associated with lower serum arsenic levels. Subsequent causal mediation analysis further showed that increased milk intake reduced the prevalence of arsenic-mediated hypertension by lowering serum arsenic levels. Additionally, our cell-free assay revealed the adsorption-modifying effect of milk on arsenic components in a popular fish meat. An in vivo assay confirmed that milk intake significantly decreased total serum arsenic levels in mice. Conclusions: Our multidisciplinary approach, combining epidemiological, chemical and animal studies, suggests that milk consumption has a beneficial effect in reducing the prevalence of arsenic-induced hypertension by decreasing arsenic absorption. Considering the global trend for increased consumption of fish meat with high levels of total arsenic, milk may be globally useful for reducing the risk of arsenic-mediated hypertension. |
| format | Article |
| id | doaj-art-00ffa329e8914d82b8f8189ffd4d0598 |
| institution | DOAJ |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-00ffa329e8914d82b8f8189ffd4d05982025-08-20T03:03:58ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130211858110.1016/j.ecoenv.2025.118581Milk intake reduced the prevalence of hypertension by decreasing total arsenic levels in fasting serum in Japanese residentsTingchao He0Yuqi Deng1Nobutaka Ohgami2Takumi Kagawa3Akira Tazaki4Akihito Harusato5Shoko Ohnuma6Hisao Naito7Takashi Tamura8Kenji Wakai9Masashi Kato10Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan; Department of Hygiene, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan; Voluntary Body for International Health Care in Universities, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan; Department of Hygiene, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan; Voluntary Body for International Health Care in Universities, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan; Department of Hygiene, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan; Voluntary Body for International Health Care in Universities, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan; Corresponding authors at: Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan; Voluntary Body for International Health Care in Universities, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan; Voluntary Body for International Health Care in Universities, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan; Institutes of Innovation for Future Society, Nagoya University, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan; Voluntary Body for International Health Care in Universities, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, JapanVoluntary Body for International Health Care in Universities, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan; Voluntary Body for International Health Care in Universities, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan; Institutes of Innovation for Future Society, Nagoya University, Japan; Corresponding authors at: Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.Background: Exposure to arsenic increases the risk of hypertension. Indeed, a high level of arsenic in human serum, a reliable biomarker of arsenic exposure, was shown to be linked to increased prevalence of hypertension among a study of Japanese residents. However, no beneficial food that decreases the risk of arsenic-mediated hypertension has been determined by considering intake scores of multiple foods. Methods: The comprehensive effects of combined beverage intake on the risk of hypertension, mediated by decreased levels of total arsenic in fasting serum, were investigated among the same group of 2706 residents. Results: Our generalized linear regression analysis for each beverage showed significant negative associations of serum arsenic levels with milk and vegetable juice intake scores among 11 beverages. Weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) analyses of combined beverage intake scores reveal that milk was the beverage most strongly associated with lower serum arsenic levels. Subsequent causal mediation analysis further showed that increased milk intake reduced the prevalence of arsenic-mediated hypertension by lowering serum arsenic levels. Additionally, our cell-free assay revealed the adsorption-modifying effect of milk on arsenic components in a popular fish meat. An in vivo assay confirmed that milk intake significantly decreased total serum arsenic levels in mice. Conclusions: Our multidisciplinary approach, combining epidemiological, chemical and animal studies, suggests that milk consumption has a beneficial effect in reducing the prevalence of arsenic-induced hypertension by decreasing arsenic absorption. Considering the global trend for increased consumption of fish meat with high levels of total arsenic, milk may be globally useful for reducing the risk of arsenic-mediated hypertension.http://www.sciencedirect.com/science/article/pii/S0147651325009261BeverageMilkArsenicFasting serumHypertensionJapanese residents |
| spellingShingle | Tingchao He Yuqi Deng Nobutaka Ohgami Takumi Kagawa Akira Tazaki Akihito Harusato Shoko Ohnuma Hisao Naito Takashi Tamura Kenji Wakai Masashi Kato Milk intake reduced the prevalence of hypertension by decreasing total arsenic levels in fasting serum in Japanese residents Ecotoxicology and Environmental Safety Beverage Milk Arsenic Fasting serum Hypertension Japanese residents |
| title | Milk intake reduced the prevalence of hypertension by decreasing total arsenic levels in fasting serum in Japanese residents |
| title_full | Milk intake reduced the prevalence of hypertension by decreasing total arsenic levels in fasting serum in Japanese residents |
| title_fullStr | Milk intake reduced the prevalence of hypertension by decreasing total arsenic levels in fasting serum in Japanese residents |
| title_full_unstemmed | Milk intake reduced the prevalence of hypertension by decreasing total arsenic levels in fasting serum in Japanese residents |
| title_short | Milk intake reduced the prevalence of hypertension by decreasing total arsenic levels in fasting serum in Japanese residents |
| title_sort | milk intake reduced the prevalence of hypertension by decreasing total arsenic levels in fasting serum in japanese residents |
| topic | Beverage Milk Arsenic Fasting serum Hypertension Japanese residents |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325009261 |
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