Genomic and immune profiling of prognostic risk groups in IgM gammopathy reveals novel biomarkers beyond MYD88 L265P

Genomic and immune profiling of prognostic risk groups in IgM gammopathy reveals novel biomarkers beyond MYD88 L265P

BackgroundMYD88 L265P is an early mutation in IgM monoclonal gammopathy of undetermined significance (MGUS) and asymptomatic Waldenström macroglobulinemia (WM). Given the high prevalence of the MYD88 mutation observed in epidemiological studies, its presence is not sufficient to drive disease progre...

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Main Authors: David F. Moreno, Ferran Nadeu, Fara Brasó-Maristany, Sergi Vaqué, Sara Paz, Joan Mañé, Oriol Cardús, Elena Medina, Ester Lozano, Luis Gerardo Rodríguez-Lobato, Anna de Daniel, Natalia Tovar, María T. Cibeira, Joan Bladé, Laura Rosiñol, Aleix Prat, Dolors Colomer, Carlos Fernández de Larrea
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
MGUS
Waldenström
MYD88
CXCR4
immune
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604089/full
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