Hereditary alpha tryptasemia and food allergy
Food allergy (FA) and hereditary alpha-tryptasemia (HαT) are both relatively common conditions, but potential associations between these diagnoses have not been well-studied. Prior studies have suggested that acute rises in tryptase following food allergy reactions may not be as significant as react...
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| Format: | Article |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Allergy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2025.1583462/full |
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| author | Abigail Lang |
| author_facet | Abigail Lang |
| author_sort | Abigail Lang |
| collection | DOAJ |
| description | Food allergy (FA) and hereditary alpha-tryptasemia (HαT) are both relatively common conditions, but potential associations between these diagnoses have not been well-studied. Prior studies have suggested that acute rises in tryptase following food allergy reactions may not be as significant as reactions triggered by venom or drug allergy, but preliminary evidence suggests that the presence of α-tryptase and HαT is a risk factor for more severe reactions to foods. This mini review summarizes the epidemiology and diagnostic considerations of FA for patients with co-morbid HαT, potential effect of α-tryptase on food allergy reaction severity, and implications of tryptase genotyping in the management of FA. Additional research is needed to further investigate the relationship between FA and HαT. |
| format | Article |
| id | doaj-art-00ec4fbc04414b58b0b350558e8a9a16 |
| institution | OA Journals |
| issn | 2673-6101 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj-art-00ec4fbc04414b58b0b350558e8a9a162025-08-20T01:52:18ZengFrontiers Media S.A.Frontiers in Allergy2673-61012025-05-01610.3389/falgy.2025.15834621583462Hereditary alpha tryptasemia and food allergyAbigail LangFood allergy (FA) and hereditary alpha-tryptasemia (HαT) are both relatively common conditions, but potential associations between these diagnoses have not been well-studied. Prior studies have suggested that acute rises in tryptase following food allergy reactions may not be as significant as reactions triggered by venom or drug allergy, but preliminary evidence suggests that the presence of α-tryptase and HαT is a risk factor for more severe reactions to foods. This mini review summarizes the epidemiology and diagnostic considerations of FA for patients with co-morbid HαT, potential effect of α-tryptase on food allergy reaction severity, and implications of tryptase genotyping in the management of FA. Additional research is needed to further investigate the relationship between FA and HαT.https://www.frontiersin.org/articles/10.3389/falgy.2025.1583462/fullfood allergyhereditary alpha tryptasaemiaTPSAB1 genefood allergy severitybiomarkeralpha-tryptasemia |
| spellingShingle | Abigail Lang Hereditary alpha tryptasemia and food allergy Frontiers in Allergy food allergy hereditary alpha tryptasaemia TPSAB1 gene food allergy severity biomarker alpha-tryptasemia |
| title | Hereditary alpha tryptasemia and food allergy |
| title_full | Hereditary alpha tryptasemia and food allergy |
| title_fullStr | Hereditary alpha tryptasemia and food allergy |
| title_full_unstemmed | Hereditary alpha tryptasemia and food allergy |
| title_short | Hereditary alpha tryptasemia and food allergy |
| title_sort | hereditary alpha tryptasemia and food allergy |
| topic | food allergy hereditary alpha tryptasaemia TPSAB1 gene food allergy severity biomarker alpha-tryptasemia |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2025.1583462/full |
| work_keys_str_mv | AT abigaillang hereditaryalphatryptasemiaandfoodallergy |