Polyethylene glycol versus lactulose in the treatment of chronic functional constipation in children: A randomized clinical trial
Background and aims: Constipation in children is a serious problem that affects both children and their families. We aimed to compare the clinical efficacy of lactulose and polyethylene glycol in the treatment of constipation in children. Methods: This randomized clinical trial was performed on 92 p...
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Shahrekord University of Medical Sciences
2024-12-01
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| Series: | Journal of Shahrekord University of Medical Sciences |
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| Online Access: | https://j.skums.ac.ir/PDF/jskums-26-140.pdf |
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| author | Hassan Talakesh Alizamen Salehifard Jouneghani Karamali Kasiri Farnoush Kochekian Afsaneh Malekpour Tehrani |
| author_facet | Hassan Talakesh Alizamen Salehifard Jouneghani Karamali Kasiri Farnoush Kochekian Afsaneh Malekpour Tehrani |
| author_sort | Hassan Talakesh |
| collection | DOAJ |
| description | Background and aims: Constipation in children is a serious problem that affects both children and their families. We aimed to compare the clinical efficacy of lactulose and polyethylene glycol in the treatment of constipation in children. Methods: This randomized clinical trial was performed on 92 patients referred to a private gastroenterology clinic in Shahrekord, Iran. The patients were randomly assigned into two groups receiving polyethylene glycol or lactulose. Defecation patterns and complications were assessed 0, 3, 7, and 21 days after the intervention. Data were analyzed using the chi-square test, repeated measures test, Mann–Whitney U test in SPSS version 16.0. P<0.05 was considered statistically significant. Results: No difference was found between the two interventional groups in terms of the frequency of painful defecation (P=0.31), fecal incontinence (P=0.50), hard stools (P=0.69), fear of defecation (P=0.09), poor appetite (P=0.29), straining at stool (P=0.50), and abdominal pain (P=0.07) within a follow-up period of 21 days. There were significant differences in the frequency of defecation on days 7 and 21 (P=0.02). The mean frequencies of abdominal cramps were significantly higher in those who received lactulose (P=0.001). The rate of nausea and vomiting was 10.6% in the lactulose group and 4.3% in the polyethylene glycol group, indicating no difference between the two groups (P=0.221). Conclusion: The administration of polyethylene glycol and lactulose had no significant difference in reducing the symptoms of chronic functional constipation in children. However, it seems that polyphenol glycol played a role in increasing the frequency of defecation. |
| format | Article |
| id | doaj-art-00eb053dbb7d40d1949fbc67ce90faaa |
| institution | OA Journals |
| issn | 2717-0071 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of Shahrekord University of Medical Sciences |
| spelling | doaj-art-00eb053dbb7d40d1949fbc67ce90faaa2025-08-20T01:49:47ZengShahrekord University of Medical SciencesJournal of Shahrekord University of Medical Sciences2717-00712024-12-0126414014510.34172/jsums.892jskums-892Polyethylene glycol versus lactulose in the treatment of chronic functional constipation in children: A randomized clinical trialHassan Talakesh0Alizamen Salehifard Jouneghani1Karamali Kasiri2Farnoush Kochekian3Afsaneh Malekpour Tehrani4Department of Pediatrics, Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Pediatrics, Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Pediatrics, Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, IranClinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Community Medicine, School of Medicine, Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranBackground and aims: Constipation in children is a serious problem that affects both children and their families. We aimed to compare the clinical efficacy of lactulose and polyethylene glycol in the treatment of constipation in children. Methods: This randomized clinical trial was performed on 92 patients referred to a private gastroenterology clinic in Shahrekord, Iran. The patients were randomly assigned into two groups receiving polyethylene glycol or lactulose. Defecation patterns and complications were assessed 0, 3, 7, and 21 days after the intervention. Data were analyzed using the chi-square test, repeated measures test, Mann–Whitney U test in SPSS version 16.0. P<0.05 was considered statistically significant. Results: No difference was found between the two interventional groups in terms of the frequency of painful defecation (P=0.31), fecal incontinence (P=0.50), hard stools (P=0.69), fear of defecation (P=0.09), poor appetite (P=0.29), straining at stool (P=0.50), and abdominal pain (P=0.07) within a follow-up period of 21 days. There were significant differences in the frequency of defecation on days 7 and 21 (P=0.02). The mean frequencies of abdominal cramps were significantly higher in those who received lactulose (P=0.001). The rate of nausea and vomiting was 10.6% in the lactulose group and 4.3% in the polyethylene glycol group, indicating no difference between the two groups (P=0.221). Conclusion: The administration of polyethylene glycol and lactulose had no significant difference in reducing the symptoms of chronic functional constipation in children. However, it seems that polyphenol glycol played a role in increasing the frequency of defecation.https://j.skums.ac.ir/PDF/jskums-26-140.pdfconstipationpolyethylene glycollactulosechildren |
| spellingShingle | Hassan Talakesh Alizamen Salehifard Jouneghani Karamali Kasiri Farnoush Kochekian Afsaneh Malekpour Tehrani Polyethylene glycol versus lactulose in the treatment of chronic functional constipation in children: A randomized clinical trial Journal of Shahrekord University of Medical Sciences constipation polyethylene glycol lactulose children |
| title | Polyethylene glycol versus lactulose in the treatment of chronic functional constipation in children: A randomized clinical trial |
| title_full | Polyethylene glycol versus lactulose in the treatment of chronic functional constipation in children: A randomized clinical trial |
| title_fullStr | Polyethylene glycol versus lactulose in the treatment of chronic functional constipation in children: A randomized clinical trial |
| title_full_unstemmed | Polyethylene glycol versus lactulose in the treatment of chronic functional constipation in children: A randomized clinical trial |
| title_short | Polyethylene glycol versus lactulose in the treatment of chronic functional constipation in children: A randomized clinical trial |
| title_sort | polyethylene glycol versus lactulose in the treatment of chronic functional constipation in children a randomized clinical trial |
| topic | constipation polyethylene glycol lactulose children |
| url | https://j.skums.ac.ir/PDF/jskums-26-140.pdf |
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