Influence of false lumen status on systemic inflammatory response triggered by acute aortic dissection
Abstract We investigated the influence of false lumen (FL) status on the systemic inflammatory response triggered by acute aortic dissection (AAD) using cytokine profiling. The study included 44 patients with AAD. Patients were divided between those with a thrombosed FL (Group T, n = 21) and those w...
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Nature Portfolio
2025-01-01
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| author | Naoyuki Kimura Yojiro Machii Daijiro Hori Makiko Mieno Naoki Eguchi Manabu Shiraishi Atsushi Yamaguchi Kenji Matsumoto Masashi Tanaka |
| author_facet | Naoyuki Kimura Yojiro Machii Daijiro Hori Makiko Mieno Naoki Eguchi Manabu Shiraishi Atsushi Yamaguchi Kenji Matsumoto Masashi Tanaka |
| author_sort | Naoyuki Kimura |
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| description | Abstract We investigated the influence of false lumen (FL) status on the systemic inflammatory response triggered by acute aortic dissection (AAD) using cytokine profiling. The study included 44 patients with AAD. Patients were divided between those with a thrombosed FL (Group T, n = 21) and those with a non-thrombosed FL (Group P, n = 23). On-admission serum concentrations of 29 cytokines were compared between unmatched and propensity-score matched (n = 10 pairs) FL groups and a control group (non-ruptured thoracic aortic aneurysm, Group C, n = 20). Unmatched analysis showed 12 cytokines differed between groups and fell into three categories: Category A (increased expression in both FL groups: IL-6, IL-10, IL-15, G-CSF); Category B (increased expression only in Group P: IL-1Ra, IL-1β, IL-8, IL-12p70, GM-CSF); and Category C (others: IP-10, VEGF-A, eotaxin). The increases in Category A and Category B cytokines in Group T were attenuated, but not significantly, compared to their increases in Group P. Propensity-score matching analysis revealed a similar expression pattern with respect to all four Category A cytokines, four Category B cytokines (IL-1β, IL-1Ra, IL-12p70, and GM-CSF), and two Category C cytokines (IP-10 and VEGF-A). A robust inflammatory response occurs in patients with AAD, but the response is attenuated when the FL is thrombosed. |
| format | Article |
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| institution | Kabale University |
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| spelling | doaj-art-00eab15b57644307ab1e2bbe9114444c2025-01-05T12:22:12ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-024-84117-5Influence of false lumen status on systemic inflammatory response triggered by acute aortic dissectionNaoyuki Kimura0Yojiro Machii1Daijiro Hori2Makiko Mieno3Naoki Eguchi4Manabu Shiraishi5Atsushi Yamaguchi6Kenji Matsumoto7Masashi Tanaka8Division of Cardiovascular Surgery, Department of Surgery, Jichi Medical UniversityDepartment of Cardiovascular Surgery, Nihon University HospitalDepartment of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical UniversityDepartment of Medical Informatics, Center for Information, Jichi Medical UniversityDepartment of Cardiovascular Surgery, Nihon University HospitalDepartment of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical UniversityDepartment of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical UniversityDepartment of Allergy and Clinical Immunology, National Research Institute for Child Health and DevelopmentDepartment of Cardiovascular Surgery, Nihon University HospitalAbstract We investigated the influence of false lumen (FL) status on the systemic inflammatory response triggered by acute aortic dissection (AAD) using cytokine profiling. The study included 44 patients with AAD. Patients were divided between those with a thrombosed FL (Group T, n = 21) and those with a non-thrombosed FL (Group P, n = 23). On-admission serum concentrations of 29 cytokines were compared between unmatched and propensity-score matched (n = 10 pairs) FL groups and a control group (non-ruptured thoracic aortic aneurysm, Group C, n = 20). Unmatched analysis showed 12 cytokines differed between groups and fell into three categories: Category A (increased expression in both FL groups: IL-6, IL-10, IL-15, G-CSF); Category B (increased expression only in Group P: IL-1Ra, IL-1β, IL-8, IL-12p70, GM-CSF); and Category C (others: IP-10, VEGF-A, eotaxin). The increases in Category A and Category B cytokines in Group T were attenuated, but not significantly, compared to their increases in Group P. Propensity-score matching analysis revealed a similar expression pattern with respect to all four Category A cytokines, four Category B cytokines (IL-1β, IL-1Ra, IL-12p70, and GM-CSF), and two Category C cytokines (IP-10 and VEGF-A). A robust inflammatory response occurs in patients with AAD, but the response is attenuated when the FL is thrombosed.https://doi.org/10.1038/s41598-024-84117-5Acute aortic dissectionInflammatory responseCytokineFalse lumen |
| spellingShingle | Naoyuki Kimura Yojiro Machii Daijiro Hori Makiko Mieno Naoki Eguchi Manabu Shiraishi Atsushi Yamaguchi Kenji Matsumoto Masashi Tanaka Influence of false lumen status on systemic inflammatory response triggered by acute aortic dissection Scientific Reports Acute aortic dissection Inflammatory response Cytokine False lumen |
| title | Influence of false lumen status on systemic inflammatory response triggered by acute aortic dissection |
| title_full | Influence of false lumen status on systemic inflammatory response triggered by acute aortic dissection |
| title_fullStr | Influence of false lumen status on systemic inflammatory response triggered by acute aortic dissection |
| title_full_unstemmed | Influence of false lumen status on systemic inflammatory response triggered by acute aortic dissection |
| title_short | Influence of false lumen status on systemic inflammatory response triggered by acute aortic dissection |
| title_sort | influence of false lumen status on systemic inflammatory response triggered by acute aortic dissection |
| topic | Acute aortic dissection Inflammatory response Cytokine False lumen |
| url | https://doi.org/10.1038/s41598-024-84117-5 |
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