Global DNA methylation of ischemic stroke subtypes.
Ischemic stroke (IS), a heterogeneous multifactorial disorder, is among the leading causes of mortality and long-term disability in the western world. Epidemiological data provides evidence for a genetic component to the disease, but its epigenetic involvement is still largely unknown. Epigenetic me...
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096543&type=printable |
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| author | Carolina Soriano-Tárraga Jordi Jiménez-Conde Eva Giralt-Steinhauer Marina Mola Angel Ois Ana Rodríguez-Campello Elisa Cuadrado-Godia Israel Fernández-Cadenas Caty Carrera Joan Montaner Roberto Elosua Jaume Roquer GeneStroke “The Spanish Stroke Genetics Consortium” |
| author_facet | Carolina Soriano-Tárraga Jordi Jiménez-Conde Eva Giralt-Steinhauer Marina Mola Angel Ois Ana Rodríguez-Campello Elisa Cuadrado-Godia Israel Fernández-Cadenas Caty Carrera Joan Montaner Roberto Elosua Jaume Roquer GeneStroke “The Spanish Stroke Genetics Consortium” |
| author_sort | Carolina Soriano-Tárraga |
| collection | DOAJ |
| description | Ischemic stroke (IS), a heterogeneous multifactorial disorder, is among the leading causes of mortality and long-term disability in the western world. Epidemiological data provides evidence for a genetic component to the disease, but its epigenetic involvement is still largely unknown. Epigenetic mechanisms, such as DNA methylation, change over time and may be associated with aging processes and with modulation of the risk of various pathologies, such as cardiovascular disease and stroke. We analyzed 2 independent cohorts of IS patients. Global DNA methylation was measured by luminometric methylation assay (LUMA) of DNA blood samples. Univariate and multivariate regression analyses were used to assess the methylation differences between the 3 most common IS subtypes, large-artery atherosclerosis (LAA), small-artery disease (SAD), and cardio-aortic embolism (CE). A total of 485 IS patients from 2 independent hospital cohorts (n = 281 and n = 204) were included, distributed across 3 IS subtypes: LAA (78/281, 59/204), SAD (97/281, 53/204), and CE (106/281, 89/204). In univariate analyses, no statistical differences in LUMA levels were observed between the 3 etiologies in either cohort. Multivariate analysis, adjusted by age, sex, hyperlipidemia, and smoking habit, confirmed the lack of differences in methylation levels between the analyzed IS subtypes in both cohorts. Despite differences in pathogenesis, our results showed no global methylation differences between LAA, SAD, and CE subtypes of IS. Further work is required to establish whether the epigenetic mechanism of methylation might play a role in this complex disease. |
| format | Article |
| id | doaj-art-00e9c660ea714c4eb765b9c52e27217f |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-00e9c660ea714c4eb765b9c52e27217f2025-08-20T02:14:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9654310.1371/journal.pone.0096543Global DNA methylation of ischemic stroke subtypes.Carolina Soriano-TárragaJordi Jiménez-CondeEva Giralt-SteinhauerMarina MolaAngel OisAna Rodríguez-CampelloElisa Cuadrado-GodiaIsrael Fernández-CadenasCaty CarreraJoan MontanerRoberto ElosuaJaume RoquerGeneStroke“The Spanish Stroke Genetics Consortium”Ischemic stroke (IS), a heterogeneous multifactorial disorder, is among the leading causes of mortality and long-term disability in the western world. Epidemiological data provides evidence for a genetic component to the disease, but its epigenetic involvement is still largely unknown. Epigenetic mechanisms, such as DNA methylation, change over time and may be associated with aging processes and with modulation of the risk of various pathologies, such as cardiovascular disease and stroke. We analyzed 2 independent cohorts of IS patients. Global DNA methylation was measured by luminometric methylation assay (LUMA) of DNA blood samples. Univariate and multivariate regression analyses were used to assess the methylation differences between the 3 most common IS subtypes, large-artery atherosclerosis (LAA), small-artery disease (SAD), and cardio-aortic embolism (CE). A total of 485 IS patients from 2 independent hospital cohorts (n = 281 and n = 204) were included, distributed across 3 IS subtypes: LAA (78/281, 59/204), SAD (97/281, 53/204), and CE (106/281, 89/204). In univariate analyses, no statistical differences in LUMA levels were observed between the 3 etiologies in either cohort. Multivariate analysis, adjusted by age, sex, hyperlipidemia, and smoking habit, confirmed the lack of differences in methylation levels between the analyzed IS subtypes in both cohorts. Despite differences in pathogenesis, our results showed no global methylation differences between LAA, SAD, and CE subtypes of IS. Further work is required to establish whether the epigenetic mechanism of methylation might play a role in this complex disease.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096543&type=printable |
| spellingShingle | Carolina Soriano-Tárraga Jordi Jiménez-Conde Eva Giralt-Steinhauer Marina Mola Angel Ois Ana Rodríguez-Campello Elisa Cuadrado-Godia Israel Fernández-Cadenas Caty Carrera Joan Montaner Roberto Elosua Jaume Roquer GeneStroke “The Spanish Stroke Genetics Consortium” Global DNA methylation of ischemic stroke subtypes. PLoS ONE |
| title | Global DNA methylation of ischemic stroke subtypes. |
| title_full | Global DNA methylation of ischemic stroke subtypes. |
| title_fullStr | Global DNA methylation of ischemic stroke subtypes. |
| title_full_unstemmed | Global DNA methylation of ischemic stroke subtypes. |
| title_short | Global DNA methylation of ischemic stroke subtypes. |
| title_sort | global dna methylation of ischemic stroke subtypes |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096543&type=printable |
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