Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating Abscess

Invasive mucormycosis is an increasingly common cause of morbidity and mortality in hematologic malignancy patients. Early consideration of the diagnosis is essential in at-risk patients, exhibiting suggestive signs and symptoms. A 56-year-old female with acute myeloid leukemia initially presented w...

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Main Authors: Shira R. Paul, Preston S. Gable
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2019/4842150
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author Shira R. Paul
Preston S. Gable
author_facet Shira R. Paul
Preston S. Gable
author_sort Shira R. Paul
collection DOAJ
description Invasive mucormycosis is an increasingly common cause of morbidity and mortality in hematologic malignancy patients. Early consideration of the diagnosis is essential in at-risk patients, exhibiting suggestive signs and symptoms. A 56-year-old female with acute myeloid leukemia initially presented with neutropenic fever before subsequently developing dense hemiplegia due to septic emboli to the spine and multifocal abscesses. These findings were later determined to be a result of a disseminated mucor infection and represented a rare manifestation of the disease. Despite the disseminated nature of the infection, identification of the causative organism was initially impeded by limitations in obtaining a tissue sample in a severely thrombocytopenic patient, as is common among hematologic malignancy patients. As a result of this limitation, diagnosis was ultimately made via PCR on bronchiolar lavage fluid. Early consideration of the diagnosis with prompt initiation of treatment is of utmost importance in this invasive infection. Further research is needed to identify and validate rapid, minimally invasive strategies for early diagnosis of mucormycosis.
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spelling doaj-art-00e6ce4c9b404747a5e5dcbee269153d2025-02-03T06:44:26ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/48421504842150Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating AbscessShira R. Paul0Preston S. Gable1Department of Internal Medicine, Naval Hospital Camp Pendleton, Box 555191, Camp Pendleton, CA 92055, USADepartment of Hematology-Oncology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USAInvasive mucormycosis is an increasingly common cause of morbidity and mortality in hematologic malignancy patients. Early consideration of the diagnosis is essential in at-risk patients, exhibiting suggestive signs and symptoms. A 56-year-old female with acute myeloid leukemia initially presented with neutropenic fever before subsequently developing dense hemiplegia due to septic emboli to the spine and multifocal abscesses. These findings were later determined to be a result of a disseminated mucor infection and represented a rare manifestation of the disease. Despite the disseminated nature of the infection, identification of the causative organism was initially impeded by limitations in obtaining a tissue sample in a severely thrombocytopenic patient, as is common among hematologic malignancy patients. As a result of this limitation, diagnosis was ultimately made via PCR on bronchiolar lavage fluid. Early consideration of the diagnosis with prompt initiation of treatment is of utmost importance in this invasive infection. Further research is needed to identify and validate rapid, minimally invasive strategies for early diagnosis of mucormycosis.http://dx.doi.org/10.1155/2019/4842150
spellingShingle Shira R. Paul
Preston S. Gable
Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating Abscess
Case Reports in Hematology
title Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating Abscess
title_full Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating Abscess
title_fullStr Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating Abscess
title_full_unstemmed Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating Abscess
title_short Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating Abscess
title_sort mucormycosis as the elusive cause of an aortic thrombus and tissue obliterating abscess
url http://dx.doi.org/10.1155/2019/4842150
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AT prestonsgable mucormycosisastheelusivecauseofanaorticthrombusandtissueobliteratingabscess