Multi-target regulation of cellular senescence by traditional Chinese medicine: a novel strategy to preventing diabetic kidney disease
Diabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes and the leading cause of end-stage renal disease. Its pathogenesis is closely linked to cellular senescence. Studies have shown that cellular senescence drives DKD progression via multiple mechanisms, including...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2511275 |
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| _version_ | 1850212198486376448 |
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| author | Chen Wang Dongfeng Chen Yonghui Yin Xiujuan Liu Yi Liu Xiaoyun Li Chang Kong Quanlin Zhao |
| author_facet | Chen Wang Dongfeng Chen Yonghui Yin Xiujuan Liu Yi Liu Xiaoyun Li Chang Kong Quanlin Zhao |
| author_sort | Chen Wang |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes and the leading cause of end-stage renal disease. Its pathogenesis is closely linked to cellular senescence. Studies have shown that cellular senescence drives DKD progression via multiple mechanisms, including tubulointerstitial fibrosis, glomerulosclerosis, oxidative stress, and aberrant AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling. However, there remains a lack of specific therapeutic targets or effective drugs for DKD treatment. Traditional Chinese medicine (TCM), characterized by its multidimensional, multi-target, significant efficacy, and fewer adverse effects, has shown unique advantages in DKD prevention and treatment. This article systematically examines the role of cellular senescence in DKD pathogenesis and, guided by TCM theory, explores how TCM may regulate cellular senescence to mitigate DKD, offering novel perspectives for enhancing clinical management of this condition. |
| format | Article |
| id | doaj-art-00df8f5009a141e8b8a5a2e2246cf19d |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-00df8f5009a141e8b8a5a2e2246cf19d2025-08-20T02:09:24ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2511275Multi-target regulation of cellular senescence by traditional Chinese medicine: a novel strategy to preventing diabetic kidney diseaseChen Wang0Dongfeng Chen1Yonghui Yin2Xiujuan Liu3Yi Liu4Xiaoyun Li5Chang Kong6Quanlin Zhao7The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaSchool of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaSchool of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaDiabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes and the leading cause of end-stage renal disease. Its pathogenesis is closely linked to cellular senescence. Studies have shown that cellular senescence drives DKD progression via multiple mechanisms, including tubulointerstitial fibrosis, glomerulosclerosis, oxidative stress, and aberrant AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling. However, there remains a lack of specific therapeutic targets or effective drugs for DKD treatment. Traditional Chinese medicine (TCM), characterized by its multidimensional, multi-target, significant efficacy, and fewer adverse effects, has shown unique advantages in DKD prevention and treatment. This article systematically examines the role of cellular senescence in DKD pathogenesis and, guided by TCM theory, explores how TCM may regulate cellular senescence to mitigate DKD, offering novel perspectives for enhancing clinical management of this condition.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2511275Diabetic kidney diseasecellular senescencetraditional chinese medicinemechanism study |
| spellingShingle | Chen Wang Dongfeng Chen Yonghui Yin Xiujuan Liu Yi Liu Xiaoyun Li Chang Kong Quanlin Zhao Multi-target regulation of cellular senescence by traditional Chinese medicine: a novel strategy to preventing diabetic kidney disease Renal Failure Diabetic kidney disease cellular senescence traditional chinese medicine mechanism study |
| title | Multi-target regulation of cellular senescence by traditional Chinese medicine: a novel strategy to preventing diabetic kidney disease |
| title_full | Multi-target regulation of cellular senescence by traditional Chinese medicine: a novel strategy to preventing diabetic kidney disease |
| title_fullStr | Multi-target regulation of cellular senescence by traditional Chinese medicine: a novel strategy to preventing diabetic kidney disease |
| title_full_unstemmed | Multi-target regulation of cellular senescence by traditional Chinese medicine: a novel strategy to preventing diabetic kidney disease |
| title_short | Multi-target regulation of cellular senescence by traditional Chinese medicine: a novel strategy to preventing diabetic kidney disease |
| title_sort | multi target regulation of cellular senescence by traditional chinese medicine a novel strategy to preventing diabetic kidney disease |
| topic | Diabetic kidney disease cellular senescence traditional chinese medicine mechanism study |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2511275 |
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