Platinum nanoparticles decorated on electrodeposited Ti3C2Tx MXene nanosheets as an ultrasensitive biosensor for CA15–3 detection
In this study, an efficient and ultrasensitive biosensor based on platinum nanoparticles decorated on MXene nanosheets (NSs) was reported for the detection of CA15–3 breast cancer biomarker. In order to increase the accuracy and reproducibility of the fabricated biosensor, MXene NSs and platinum nan...
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Elsevier
2025-06-01
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| Series: | Sensors and Actuators Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666053924000948 |
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| author | Sepideh Shafaei Rahim Mohammad-Rezaei Balal Khalilzadeh Ibrahim Isildak |
| author_facet | Sepideh Shafaei Rahim Mohammad-Rezaei Balal Khalilzadeh Ibrahim Isildak |
| author_sort | Sepideh Shafaei |
| collection | DOAJ |
| description | In this study, an efficient and ultrasensitive biosensor based on platinum nanoparticles decorated on MXene nanosheets (NSs) was reported for the detection of CA15–3 breast cancer biomarker. In order to increase the accuracy and reproducibility of the fabricated biosensor, MXene NSs and platinum nanoparticles (PtNPs) were electrochemically deposited on the surface of glassy carbon electrode (MXene-Pt/GCE). The synergistic effect of MXene and PtNPs caused an increased conductivity, fast electron transfers, amplified sensitivity and improved stabilization of streptavidin and CA15–3 antibody on the electrode surface. According to the electrochemical results, the electroactive surface area of MXene-Pt/GCE was obtained 0.1345 cm2 which was remarkably more than GCE. The detection limit and linear range for the developed CA15–3 breast cancer biosensor were 1 nU and 1 to 100 nU, respectively. Based on the data, the proposed biosensor exhibited unique reproducibility, stability, and selectivity which can be differentiate between the healthy serum samples and patients suffering from breast cancer. |
| format | Article |
| id | doaj-art-00dd98029aee4b569f9574d6faac8335 |
| institution | Kabale University |
| issn | 2666-0539 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensors and Actuators Reports |
| spelling | doaj-art-00dd98029aee4b569f9574d6faac83352025-01-09T06:14:36ZengElsevierSensors and Actuators Reports2666-05392025-06-019100278Platinum nanoparticles decorated on electrodeposited Ti3C2Tx MXene nanosheets as an ultrasensitive biosensor for CA15–3 detectionSepideh Shafaei0Rahim Mohammad-Rezaei1Balal Khalilzadeh2Ibrahim Isildak3Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Electrochemistry Research Lab, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, IranElectrochemistry Research Lab, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran; Corresponding authors at: Department of Chemistry, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding authors at: Department of Chemistry, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.Department of Bioengineering, Faculty of Chemistry-Metallurgy, Yildiz Technical University, Istanbul, TurkeyIn this study, an efficient and ultrasensitive biosensor based on platinum nanoparticles decorated on MXene nanosheets (NSs) was reported for the detection of CA15–3 breast cancer biomarker. In order to increase the accuracy and reproducibility of the fabricated biosensor, MXene NSs and platinum nanoparticles (PtNPs) were electrochemically deposited on the surface of glassy carbon electrode (MXene-Pt/GCE). The synergistic effect of MXene and PtNPs caused an increased conductivity, fast electron transfers, amplified sensitivity and improved stabilization of streptavidin and CA15–3 antibody on the electrode surface. According to the electrochemical results, the electroactive surface area of MXene-Pt/GCE was obtained 0.1345 cm2 which was remarkably more than GCE. The detection limit and linear range for the developed CA15–3 breast cancer biosensor were 1 nU and 1 to 100 nU, respectively. Based on the data, the proposed biosensor exhibited unique reproducibility, stability, and selectivity which can be differentiate between the healthy serum samples and patients suffering from breast cancer.http://www.sciencedirect.com/science/article/pii/S2666053924000948Mxene nanosheetsPlatinum nanoparticlesBiosensorBreast cancerCA15–3Ultrasensitive Detection |
| spellingShingle | Sepideh Shafaei Rahim Mohammad-Rezaei Balal Khalilzadeh Ibrahim Isildak Platinum nanoparticles decorated on electrodeposited Ti3C2Tx MXene nanosheets as an ultrasensitive biosensor for CA15–3 detection Sensors and Actuators Reports Mxene nanosheets Platinum nanoparticles Biosensor Breast cancer CA15–3 Ultrasensitive Detection |
| title | Platinum nanoparticles decorated on electrodeposited Ti3C2Tx MXene nanosheets as an ultrasensitive biosensor for CA15–3 detection |
| title_full | Platinum nanoparticles decorated on electrodeposited Ti3C2Tx MXene nanosheets as an ultrasensitive biosensor for CA15–3 detection |
| title_fullStr | Platinum nanoparticles decorated on electrodeposited Ti3C2Tx MXene nanosheets as an ultrasensitive biosensor for CA15–3 detection |
| title_full_unstemmed | Platinum nanoparticles decorated on electrodeposited Ti3C2Tx MXene nanosheets as an ultrasensitive biosensor for CA15–3 detection |
| title_short | Platinum nanoparticles decorated on electrodeposited Ti3C2Tx MXene nanosheets as an ultrasensitive biosensor for CA15–3 detection |
| title_sort | platinum nanoparticles decorated on electrodeposited ti3c2tx mxene nanosheets as an ultrasensitive biosensor for ca15 3 detection |
| topic | Mxene nanosheets Platinum nanoparticles Biosensor Breast cancer CA15–3 Ultrasensitive Detection |
| url | http://www.sciencedirect.com/science/article/pii/S2666053924000948 |
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