Molecular Networking Combined with MALDI-MSI Reveals New Lanostane-Type Triterpenoids with Anti-Hepatocellular Carcinoma Activity and Their Spatial Distribution in the Fruit Body of Ganoderma leucocontextum

Saved in:
Bibliographic Details
Main Authors: Wang Dong, Xiaobing Jiang, Jing Dong, Junjie Han, Jingzu Sun, Wenzhao Wang, Xiaodong Li, Yajuan Lei, Tuya Wuren, Ningning Liu, Hongwei Liu, Baosong Chen
Format: Article
Language:English
Published: American Chemical Society 2025-06-01
Series:ACS Omega
Online Access:https://doi.org/10.1021/acsomega.5c01716
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1849690076178546688
author Wang Dong
Xiaobing Jiang
Jing Dong
Junjie Han
Jingzu Sun
Wenzhao Wang
Xiaodong Li
Yajuan Lei
Tuya Wuren
Ningning Liu
Hongwei Liu
Baosong Chen
author_facet Wang Dong
Xiaobing Jiang
Jing Dong
Junjie Han
Jingzu Sun
Wenzhao Wang
Xiaodong Li
Yajuan Lei
Tuya Wuren
Ningning Liu
Hongwei Liu
Baosong Chen
author_sort Wang Dong
collection DOAJ
format Article
id doaj-art-00dd608c6bb042cb8e1592d164dbb249
institution DOAJ
issn 2470-1343
language English
publishDate 2025-06-01
publisher American Chemical Society
record_format Article
series ACS Omega
spelling doaj-art-00dd608c6bb042cb8e1592d164dbb2492025-08-20T03:21:26ZengAmerican Chemical SocietyACS Omega2470-13432025-06-011023247402475510.1021/acsomega.5c01716Molecular Networking Combined with MALDI-MSI Reveals New Lanostane-Type Triterpenoids with Anti-Hepatocellular Carcinoma Activity and Their Spatial Distribution in the Fruit Body of Ganoderma leucocontextumWang Dong0Xiaobing Jiang1Jing Dong2Junjie Han3Jingzu Sun4Wenzhao Wang5Xiaodong Li6Yajuan Lei7Tuya Wuren8Ningning Liu9Hongwei Liu10Baosong Chen11State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaShimadzu China Innovation Center, Shimadzu Corporation, Beijing, ChinaState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaShimadzu China Innovation Center, Shimadzu Corporation, Beijing, ChinaShimadzu China Innovation Center, Shimadzu Corporation, Beijing, ChinaOrdos Mongolian Hospital, Ordos, ChinaCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaCollege of Bioengineering, Tianjin University of Science and Technology, Tianjin, Chinahttps://doi.org/10.1021/acsomega.5c01716
spellingShingle Wang Dong
Xiaobing Jiang
Jing Dong
Junjie Han
Jingzu Sun
Wenzhao Wang
Xiaodong Li
Yajuan Lei
Tuya Wuren
Ningning Liu
Hongwei Liu
Baosong Chen
Molecular Networking Combined with MALDI-MSI Reveals New Lanostane-Type Triterpenoids with Anti-Hepatocellular Carcinoma Activity and Their Spatial Distribution in the Fruit Body of Ganoderma leucocontextum
ACS Omega
title Molecular Networking Combined with MALDI-MSI Reveals New Lanostane-Type Triterpenoids with Anti-Hepatocellular Carcinoma Activity and Their Spatial Distribution in the Fruit Body of Ganoderma leucocontextum
title_full Molecular Networking Combined with MALDI-MSI Reveals New Lanostane-Type Triterpenoids with Anti-Hepatocellular Carcinoma Activity and Their Spatial Distribution in the Fruit Body of Ganoderma leucocontextum
title_fullStr Molecular Networking Combined with MALDI-MSI Reveals New Lanostane-Type Triterpenoids with Anti-Hepatocellular Carcinoma Activity and Their Spatial Distribution in the Fruit Body of Ganoderma leucocontextum
title_full_unstemmed Molecular Networking Combined with MALDI-MSI Reveals New Lanostane-Type Triterpenoids with Anti-Hepatocellular Carcinoma Activity and Their Spatial Distribution in the Fruit Body of Ganoderma leucocontextum
title_short Molecular Networking Combined with MALDI-MSI Reveals New Lanostane-Type Triterpenoids with Anti-Hepatocellular Carcinoma Activity and Their Spatial Distribution in the Fruit Body of Ganoderma leucocontextum
title_sort molecular networking combined with maldi msi reveals new lanostane type triterpenoids with anti hepatocellular carcinoma activity and their spatial distribution in the fruit body of ganoderma leucocontextum
url https://doi.org/10.1021/acsomega.5c01716
work_keys_str_mv AT wangdong molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum
AT xiaobingjiang molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum
AT jingdong molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum
AT junjiehan molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum
AT jingzusun molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum
AT wenzhaowang molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum
AT xiaodongli molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum
AT yajuanlei molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum
AT tuyawuren molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum
AT ningningliu molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum
AT hongweiliu molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum
AT baosongchen molecularnetworkingcombinedwithmaldimsirevealsnewlanostanetypetriterpenoidswithantihepatocellularcarcinomaactivityandtheirspatialdistributioninthefruitbodyofganodermaleucocontextum