Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State
Several kinetic models for the macrocyclization of a C2 pseudopeptide with a dihalide through a SN2 reaction have been developed. These models not only focus on the kinetic analysis of the main macrocyclization reaction, but also consider the competitive oligomerization/polymerization processes yiel...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/748251 |
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| author | Vicente Martí-Centelles M. Isabel Burguete Santiago V. Luis |
| author_facet | Vicente Martí-Centelles M. Isabel Burguete Santiago V. Luis |
| author_sort | Vicente Martí-Centelles |
| collection | DOAJ |
| description | Several kinetic models for the macrocyclization of a C2 pseudopeptide with a dihalide through a SN2 reaction have been developed. These models not only focus on the kinetic analysis of the main macrocyclization reaction, but also consider the
competitive oligomerization/polymerization processes yielding undesired oligomeric/polymeric byproducts. The effect of anions has also been included in the kinetic models, as they can act as catalytic templates in the transition state reducing and stabilizing the transition state. The corresponding differential equation systems for each kinetic model can be solved numerically. Through a comprehensive analysis of these results, it is possible to obtain a better understanding of the different parameters that are involved in the macrocyclization reaction mechanism and to develop strategies for the optimization of the desired processes. |
| format | Article |
| id | doaj-art-00d7e82343e342f78f671d0e125b6146 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-00d7e82343e342f78f671d0e125b61462025-02-03T01:30:54ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/748251748251Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition StateVicente Martí-Centelles0M. Isabel Burguete1Santiago V. Luis2Departamento de Química Inorgánica y Orgánica, Universitat Jaume I, E12071 Castellón de la Plana, SpainDepartamento de Química Inorgánica y Orgánica, Universitat Jaume I, E12071 Castellón de la Plana, SpainDepartamento de Química Inorgánica y Orgánica, Universitat Jaume I, E12071 Castellón de la Plana, SpainSeveral kinetic models for the macrocyclization of a C2 pseudopeptide with a dihalide through a SN2 reaction have been developed. These models not only focus on the kinetic analysis of the main macrocyclization reaction, but also consider the competitive oligomerization/polymerization processes yielding undesired oligomeric/polymeric byproducts. The effect of anions has also been included in the kinetic models, as they can act as catalytic templates in the transition state reducing and stabilizing the transition state. The corresponding differential equation systems for each kinetic model can be solved numerically. Through a comprehensive analysis of these results, it is possible to obtain a better understanding of the different parameters that are involved in the macrocyclization reaction mechanism and to develop strategies for the optimization of the desired processes.http://dx.doi.org/10.1100/2012/748251 |
| spellingShingle | Vicente Martí-Centelles M. Isabel Burguete Santiago V. Luis Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State The Scientific World Journal |
| title | Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State |
| title_full | Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State |
| title_fullStr | Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State |
| title_full_unstemmed | Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State |
| title_short | Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State |
| title_sort | kinetic analysis for macrocyclizations involving anionic template at the transition state |
| url | http://dx.doi.org/10.1100/2012/748251 |
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