Insertion sequence-mediated phage resistance contributes to attenuated colonization of cytolytic Enterococcus faecalis variants in the gut

Insertion sequence-mediated phage resistance contributes to attenuated colonization of cytolytic Enterococcus faecalis variants in the gut

ABSTRACT Specific elimination of cytolytic Enterococcus faecalis from the intestinal microbiota by bacteriophages (phages) attenuates ethanol-induced liver disease in pre-clinical studies; however, other clinical phage therapy studies have reported the occurrence of phage-resistant variants. Here, w...

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Bibliographic Details
Main Authors: Jumpei Fujiki, Tomohiro Nakamura, Henriette Kreimeyer, Cristina Llorente, Derrick E. Fouts, Bernd Schnabl
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
phage therapy
bacteriophage
microbiome editing
gut-liver axis
cytolysin
trade-off
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03303-24
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