Chemical Space for Peptide-based Antimicrobials
Multidrug-resistant (MDR) bacteria represent a global public health threat, and antimicrobial peptides (AMPs), derived from naturally occurring linear or cyclic peptides, can provide the solution. However, most AMPs are sensitive to proteases and have poor pharmacokinetics. The EU-funded ERC Advance...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2024-10-01
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| Series: | CHIMIA |
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| Online Access: | https://www.chimia.ch/chimia/article/view/7347 |
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| author | Markus Orsi Hippolyte Personne Etienne Bonvin Thierry Paschoud Basak Olcay Xiaoling Hu Sacha Javor Jean-Louis Reymond |
| author_facet | Markus Orsi Hippolyte Personne Etienne Bonvin Thierry Paschoud Basak Olcay Xiaoling Hu Sacha Javor Jean-Louis Reymond |
| author_sort | Markus Orsi |
| collection | DOAJ |
| description | Multidrug-resistant (MDR) bacteria represent a global public health threat, and antimicrobial peptides (AMPs), derived from naturally occurring linear or cyclic peptides, can provide the solution. However, most AMPs are sensitive to proteases and have poor pharmacokinetics. The EU-funded ERC Advanced Grant SPACE4AMPS aims to identify new AMPs by applying the concepts of chemical space and ligand-based virtual screening, which are well known for small molecule drug discovery, to the world of peptides. We create virtual libraries of peptides and related molecules and use these approaches to select a few tens of compounds for synthesis and detailed. evaluation of antibacterial, toxicity and stability effects. Recent results and prospects of this ongoing project are presented in this review.
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| format | Article |
| id | doaj-art-00d24df2d19245198cfdf4ab7de2963d |
| institution | OA Journals |
| issn | 0009-4293 2673-2424 |
| language | deu |
| publishDate | 2024-10-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj-art-00d24df2d19245198cfdf4ab7de2963d2025-08-20T02:29:51ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242024-10-01781010.2533/chimia.2024.648Chemical Space for Peptide-based AntimicrobialsMarkus Orsi0Hippolyte Personne1Etienne Bonvin2Thierry Paschoud3Basak Olcay4Xiaoling Hu5Sacha Javor6Jean-Louis Reymond7Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, CH-3012 Bern, SwitzerlandDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, CH-3012 Bern, SwitzerlandDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, CH-3012 Bern, SwitzerlandDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, CH-3012 Bern, SwitzerlandDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, CH-3012 Bern, SwitzerlandDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, CH-3012 Bern, SwitzerlandDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, CH-3012 Bern, SwitzerlandDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, CH-3012 Bern, SwitzerlandMultidrug-resistant (MDR) bacteria represent a global public health threat, and antimicrobial peptides (AMPs), derived from naturally occurring linear or cyclic peptides, can provide the solution. However, most AMPs are sensitive to proteases and have poor pharmacokinetics. The EU-funded ERC Advanced Grant SPACE4AMPS aims to identify new AMPs by applying the concepts of chemical space and ligand-based virtual screening, which are well known for small molecule drug discovery, to the world of peptides. We create virtual libraries of peptides and related molecules and use these approaches to select a few tens of compounds for synthesis and detailed. evaluation of antibacterial, toxicity and stability effects. Recent results and prospects of this ongoing project are presented in this review. https://www.chimia.ch/chimia/article/view/7347Antimicrobial peptidesAntimicrobial resistanceChemical spacePeptoidsVirtual screening |
| spellingShingle | Markus Orsi Hippolyte Personne Etienne Bonvin Thierry Paschoud Basak Olcay Xiaoling Hu Sacha Javor Jean-Louis Reymond Chemical Space for Peptide-based Antimicrobials CHIMIA Antimicrobial peptides Antimicrobial resistance Chemical space Peptoids Virtual screening |
| title | Chemical Space for Peptide-based Antimicrobials |
| title_full | Chemical Space for Peptide-based Antimicrobials |
| title_fullStr | Chemical Space for Peptide-based Antimicrobials |
| title_full_unstemmed | Chemical Space for Peptide-based Antimicrobials |
| title_short | Chemical Space for Peptide-based Antimicrobials |
| title_sort | chemical space for peptide based antimicrobials |
| topic | Antimicrobial peptides Antimicrobial resistance Chemical space Peptoids Virtual screening |
| url | https://www.chimia.ch/chimia/article/view/7347 |
| work_keys_str_mv | AT markusorsi chemicalspaceforpeptidebasedantimicrobials AT hippolytepersonne chemicalspaceforpeptidebasedantimicrobials AT etiennebonvin chemicalspaceforpeptidebasedantimicrobials AT thierrypaschoud chemicalspaceforpeptidebasedantimicrobials AT basakolcay chemicalspaceforpeptidebasedantimicrobials AT xiaolinghu chemicalspaceforpeptidebasedantimicrobials AT sachajavor chemicalspaceforpeptidebasedantimicrobials AT jeanlouisreymond chemicalspaceforpeptidebasedantimicrobials |