TFF3 initiates gastric intestinal metaplasia by activating JAK2 and STAT3 under high salt conditions

TFF3 initiates gastric intestinal metaplasia by activating JAK2 and STAT3 under high salt conditions

Abstract The mechanism underlying the role of trefoil factor family 3 (TFF3) in intestinal metaplasia remains unclear. This study reveals the molecular mechanism by which TFF3, in the process of gastric mucosal epithelial cell intestinal metaplasia (IM) induced by high salt, activates the JAK2/STAT3...

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Bibliographic Details
Main Authors: Yanhong Wang, Feifei Qian, Baodong Shan, Li Zhang, Jie Zhong, Song Chen, Manman Yao, Shengnan Li, Xixiang Cao, Sujuan Fei, Xunlei Pang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Intestinal metaplasia
High salt
TFF3
JAK2/STAT3
CDX2
Online Access:https://doi.org/10.1038/s41598-025-09045-4
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