A network-based approach to overcome BCR::ABL1-independent resistance in chronic myeloid leukemia

A network-based approach to overcome BCR::ABL1-independent resistance in chronic myeloid leukemia

Abstract Background About 40% of relapsed or non-responder tumors exhibit therapeutic resistance in the absence of a clear genetic cause, suggesting a pivotal role of intracellular communication. A deeper understanding of signaling pathways rewiring occurring in resistant cells is crucial to propose...

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Main Authors: Valeria Bica, Veronica Venafra, Giorgia Massacci, Simone Graziosi, Sara Gualdi, Gessica Minnella, Federica Sorà, Patrizia Chiusolo, Maria Elsa Brunetti, Gennaro Napolitano, Massimo Breccia, Dimitrios Mougiakakos, Martin Böttcher, Thomas Fischer, Livia Perfetto, Francesca Sacco
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell Communication and Signaling
Subjects:
Chronic myeloid leukemia
BCR:ABL1-independent resistance
Signaling pathways
Phosphoproteomics
Computational strategy
Drug repurposing
Online Access:https://doi.org/10.1186/s12964-025-02185-0
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