Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology
The interaction of the neurotrophin BDNF dipeptide mimetic, compound GSB-106, with the tyrosine kinase TrkB receptor specific for the fullsized neurotrophin was studied using surface plasmon resonance. The significant decrease in the binding of BDNF to TrkB, which was preincubated with GSB-106, was...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2023-01-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/343 |
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| author | A. V. Tarasiuk Y. V. Mezentsev O. V. Gnedenko P. Yu. Povarnina A. S. Ivanov |
| author_facet | A. V. Tarasiuk Y. V. Mezentsev O. V. Gnedenko P. Yu. Povarnina A. S. Ivanov |
| author_sort | A. V. Tarasiuk |
| collection | DOAJ |
| description | The interaction of the neurotrophin BDNF dipeptide mimetic, compound GSB-106, with the tyrosine kinase TrkB receptor specific for the fullsized neurotrophin was studied using surface plasmon resonance. The significant decrease in the binding of BDNF to TrkB, which was preincubated with GSB-106, was shown. The obtained data indicate the interaction of GSB-106 with the TrkB receptor. |
| format | Article |
| id | doaj-art-00c2a6dcdaad4c679147cb8df67df9d3 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2023-01-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-00c2a6dcdaad4c679147cb8df67df9d32025-08-20T03:57:48ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302023-01-0104505410.37489/2587-7836-2022-4-50-54319Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technologyA. V. Tarasiuk0Y. V. Mezentsev1O. V. Gnedenko2P. Yu. Povarnina3A. S. Ivanov4FSBI «Zakusov Institute of Pharmacology»Institute of Biomedical Chemistry (IBMC)Institute of Biomedical Chemistry (IBMC)FSBI «Zakusov Institute of Pharmacology»Institute of Biomedical Chemistry (IBMC)The interaction of the neurotrophin BDNF dipeptide mimetic, compound GSB-106, with the tyrosine kinase TrkB receptor specific for the fullsized neurotrophin was studied using surface plasmon resonance. The significant decrease in the binding of BDNF to TrkB, which was preincubated with GSB-106, was shown. The obtained data indicate the interaction of GSB-106 with the TrkB receptor.https://www.pharmacokinetica.ru/jour/article/view/343neurotrophinbdnftrkbdimeric dipeptide mimeticoptical biosensorsurface plasmon resonance |
| spellingShingle | A. V. Tarasiuk Y. V. Mezentsev O. V. Gnedenko P. Yu. Povarnina A. S. Ivanov Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology Фармакокинетика и Фармакодинамика neurotrophin bdnf trkb dimeric dipeptide mimetic optical biosensor surface plasmon resonance |
| title | Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology |
| title_full | Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology |
| title_fullStr | Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology |
| title_full_unstemmed | Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology |
| title_short | Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology |
| title_sort | study of the interaction of the gsb 106 bdnf neurotrophin dipeptide mimetic with the trkb tyrosine kinase receptor using surface plasmon resonance technology |
| topic | neurotrophin bdnf trkb dimeric dipeptide mimetic optical biosensor surface plasmon resonance |
| url | https://www.pharmacokinetica.ru/jour/article/view/343 |
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