Role of Non-invasive Preimplantation Genetic Testing-Aneuploidy Using Spent Culture Media and its Concordance with Trophectoderm Biopsy: A Proof of Concept and Validation Study

Role of Non-invasive Preimplantation Genetic Testing-Aneuploidy Using Spent Culture Media and its Concordance with Trophectoderm Biopsy: A Proof of Concept and Validation Study

Background: While trophectoderm (TE) biopsy with next-generation sequencing (NGS) remains the gold standard for preimplantation genetic testing for aneuploidy (PGT-A), the discovery of cell-free DNA (cfDNA) in spent culture media (SCM) has sparked interest in non-invasive PGT-A (NiPGT-A) as a potent...

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Bibliographic Details
Main Authors:	Neeta Singh, Ankita Sethi, Lata Rani, Monika Saini, Ritu Gupta, Neena Malhotra, Reeta Mahey
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2025-04-01
Series:	Journal of Human Reproductive Sciences
Subjects:	cell-free dna next-generation sequencing non-invasive preimplantation genetic testing spent culture media whole genome amplification
Online Access:	https://journals.lww.com/10.4103/jhrs.jhrs_192_24
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