Monocyte distribution width (MDW) as a reliable diagnostic biomarker for sepsis in patients with HIV
Sepsis is a leading cause of death among patients with HIV, but early diagnosis remains a challenge. This study evaluates the diagnostic performance of monocyte distribution width (MDW) in detecting sepsis in patients with HIV. A prospective observational study was conducted at Shanghai Public Healt...
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Taylor & Francis Group
2025-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2025.2479634 |
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| author | Jinfeng Sun Yueming Shao Rui Jiang Tangkai Qi Jingna Xun Yinzhong Shen Renfang Zhang Liu Qian Xialin Wang Li Liu Zhenyan Wang Jianjun Sun Yang Tang Wei Song Shuibao Xu Junyang Yang Youming Chen Yi-Wei Tang Hongzhou Lu Jun Chen |
| author_facet | Jinfeng Sun Yueming Shao Rui Jiang Tangkai Qi Jingna Xun Yinzhong Shen Renfang Zhang Liu Qian Xialin Wang Li Liu Zhenyan Wang Jianjun Sun Yang Tang Wei Song Shuibao Xu Junyang Yang Youming Chen Yi-Wei Tang Hongzhou Lu Jun Chen |
| author_sort | Jinfeng Sun |
| collection | DOAJ |
| description | Sepsis is a leading cause of death among patients with HIV, but early diagnosis remains a challenge. This study evaluates the diagnostic performance of monocyte distribution width (MDW) in detecting sepsis in patients with HIV. A prospective observational study was conducted at Shanghai Public Health Center, involving 488 hospitalized patients with HIV aged 18–65 between December 2022 and August 2023. MDW was measured at admission, and its diagnostic accuracy was compared with Sepsis-3 criteria. Survival rates on day 28 and 90 were also recorded. Additionally, five machine learning (ML) models were tested to enhance diagnostic efficacy. Of 488 subjects, 90 were in the sepsis group and 398 in the control group. MDW showed a diagnostic area under the curve (AUC) of 0.82, comparable to C-reactive protein (CRP) and Procalcitonin (PCT) with AUCs of 0.78 and 0.82, respectively. With a cut-off value of 25.25, MDW had a sensitivity of 0.83 and specificity of 0.76. The positive and negative predictive values were 44% and 95%, respectively. When MDW was combined with platelet count, serum albumin, and hemoglobin in a random forest model, the AUC improved to 0.931. The model achieved a sensitivity of 1.00 and specificity of 0.732. MDW is a useful diagnostic marker for sepsis in patients with HIV, with strong sensitivity and specificity. Combining MDW with other lab markers can further enhance diagnostic accuracy.Trial registration: ClinicalTrials.gov identifier: NCT05036928.. |
| format | Article |
| id | doaj-art-00bc5772018b4e279d936a42d2c602a9 |
| institution | DOAJ |
| issn | 2222-1751 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-00bc5772018b4e279d936a42d2c602a92025-08-20T02:41:43ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512025-12-0114110.1080/22221751.2025.2479634Monocyte distribution width (MDW) as a reliable diagnostic biomarker for sepsis in patients with HIVJinfeng Sun0Yueming Shao1Rui Jiang2Tangkai Qi3Jingna Xun4Yinzhong Shen5Renfang Zhang6Liu Qian7Xialin Wang8Li Liu9Zhenyan Wang10Jianjun Sun11Yang Tang12Wei Song13Shuibao Xu14Junyang Yang15Youming Chen16Yi-Wei Tang17Hongzhou Lu18Jun Chen19Department of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaMedical Affairs Department, Beckman-Coulter, Danaher Corporation (China), Shanghai, People's Republic of ChinaMarketing Department, Beckman-Coulter, Danaher Corporation (China), Shanghai, People's Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaMedical Affairs Department, Danaher Corporation/Cepheid, New York, USADepartment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen, People’s Republic of ChinaDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaSepsis is a leading cause of death among patients with HIV, but early diagnosis remains a challenge. This study evaluates the diagnostic performance of monocyte distribution width (MDW) in detecting sepsis in patients with HIV. A prospective observational study was conducted at Shanghai Public Health Center, involving 488 hospitalized patients with HIV aged 18–65 between December 2022 and August 2023. MDW was measured at admission, and its diagnostic accuracy was compared with Sepsis-3 criteria. Survival rates on day 28 and 90 were also recorded. Additionally, five machine learning (ML) models were tested to enhance diagnostic efficacy. Of 488 subjects, 90 were in the sepsis group and 398 in the control group. MDW showed a diagnostic area under the curve (AUC) of 0.82, comparable to C-reactive protein (CRP) and Procalcitonin (PCT) with AUCs of 0.78 and 0.82, respectively. With a cut-off value of 25.25, MDW had a sensitivity of 0.83 and specificity of 0.76. The positive and negative predictive values were 44% and 95%, respectively. When MDW was combined with platelet count, serum albumin, and hemoglobin in a random forest model, the AUC improved to 0.931. The model achieved a sensitivity of 1.00 and specificity of 0.732. MDW is a useful diagnostic marker for sepsis in patients with HIV, with strong sensitivity and specificity. Combining MDW with other lab markers can further enhance diagnostic accuracy.Trial registration: ClinicalTrials.gov identifier: NCT05036928..https://www.tandfonline.com/doi/10.1080/22221751.2025.2479634Biomarkershuman immunodeficiency virus (HIV)monocyte distribution width (MDW)sepsisSepsis-3 |
| spellingShingle | Jinfeng Sun Yueming Shao Rui Jiang Tangkai Qi Jingna Xun Yinzhong Shen Renfang Zhang Liu Qian Xialin Wang Li Liu Zhenyan Wang Jianjun Sun Yang Tang Wei Song Shuibao Xu Junyang Yang Youming Chen Yi-Wei Tang Hongzhou Lu Jun Chen Monocyte distribution width (MDW) as a reliable diagnostic biomarker for sepsis in patients with HIV Emerging Microbes and Infections Biomarkers human immunodeficiency virus (HIV) monocyte distribution width (MDW) sepsis Sepsis-3 |
| title | Monocyte distribution width (MDW) as a reliable diagnostic biomarker for sepsis in patients with HIV |
| title_full | Monocyte distribution width (MDW) as a reliable diagnostic biomarker for sepsis in patients with HIV |
| title_fullStr | Monocyte distribution width (MDW) as a reliable diagnostic biomarker for sepsis in patients with HIV |
| title_full_unstemmed | Monocyte distribution width (MDW) as a reliable diagnostic biomarker for sepsis in patients with HIV |
| title_short | Monocyte distribution width (MDW) as a reliable diagnostic biomarker for sepsis in patients with HIV |
| title_sort | monocyte distribution width mdw as a reliable diagnostic biomarker for sepsis in patients with hiv |
| topic | Biomarkers human immunodeficiency virus (HIV) monocyte distribution width (MDW) sepsis Sepsis-3 |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2025.2479634 |
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