Medical Therapy of Acromegaly
This paper outlines the present status of medical therapy of acromegaly. Indications for permanent postoperative treatment, postirradiation treamtent to bridge the interval until remission as well as primary medical therapy are elaborated. Therapeutic efficacy of the different available drugs—somato...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/268957 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850232395328913408 |
|---|---|
| author | U. Plöckinger |
| author_facet | U. Plöckinger |
| author_sort | U. Plöckinger |
| collection | DOAJ |
| description | This paper outlines the present status of medical therapy of acromegaly. Indications for permanent postoperative treatment, postirradiation treamtent to bridge the interval until remission as well as primary medical therapy are elaborated. Therapeutic efficacy of the different available drugs—somatostatin receptor ligands (SRLs), dopamine agonists, and the GH antagonist Pegvisomant—is discussed, as are the indications for and efficacy of their respective combinations. Information on their mechanism of action, and some pharmakokinetic data are included. Special emphasis is given to the difficulties to define remission criteria of acromegaly due to technical assay problems. An algorithm for medical therapy in acromegaly is provided. |
| format | Article |
| id | doaj-art-00b4677bef464a95b9ac6665e8d4ae8a |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-00b4677bef464a95b9ac6665e8d4ae8a2025-08-20T02:03:13ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/268957268957Medical Therapy of AcromegalyU. Plöckinger0Interdisziplinäres Stoffwechsel-Centrum, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, 13353 Berlin, GermanyThis paper outlines the present status of medical therapy of acromegaly. Indications for permanent postoperative treatment, postirradiation treamtent to bridge the interval until remission as well as primary medical therapy are elaborated. Therapeutic efficacy of the different available drugs—somatostatin receptor ligands (SRLs), dopamine agonists, and the GH antagonist Pegvisomant—is discussed, as are the indications for and efficacy of their respective combinations. Information on their mechanism of action, and some pharmakokinetic data are included. Special emphasis is given to the difficulties to define remission criteria of acromegaly due to technical assay problems. An algorithm for medical therapy in acromegaly is provided.http://dx.doi.org/10.1155/2012/268957 |
| spellingShingle | U. Plöckinger Medical Therapy of Acromegaly International Journal of Endocrinology |
| title | Medical Therapy of Acromegaly |
| title_full | Medical Therapy of Acromegaly |
| title_fullStr | Medical Therapy of Acromegaly |
| title_full_unstemmed | Medical Therapy of Acromegaly |
| title_short | Medical Therapy of Acromegaly |
| title_sort | medical therapy of acromegaly |
| url | http://dx.doi.org/10.1155/2012/268957 |
| work_keys_str_mv | AT uplockinger medicaltherapyofacromegaly |