Polymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapy
The use of atypical antipsychotic drugs has made metabolic disorders one of the most common side effect of pharmacotherapy for schizophrenic patients. The aim of this study was to assess the contribution of polymorphic variants of genes of the P450 cytochrome system to changes in body mass index in...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-12-01
|
| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| Subjects: | |
| Online Access: | https://www.bekhterevreview.com/jour/article/view/328 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849693580661096448 |
|---|---|
| author | I. V. Pozhidaev A. S. Boiko E. G. Kornetova |
| author_facet | I. V. Pozhidaev A. S. Boiko E. G. Kornetova |
| author_sort | I. V. Pozhidaev |
| collection | DOAJ |
| description | The use of atypical antipsychotic drugs has made metabolic disorders one of the most common side effect of pharmacotherapy for schizophrenic patients. The aim of this study was to assess the contribution of polymorphic variants of genes of the P450 cytochrome system to changes in body mass index in patients with schizophrenia. As a result of the study, we did not identify significant associations of genotypes and alleles of the studied polymorphic variants of the CYP2D6, CYP1A2, CYP2C19 genes with weight gain in patients with schizophrenia of Russian nationality of the Siberian region receiving antipsychotic therapy and can revealed neither protective nor predisposing effects. Metabolic syndrome and, increase in body weight especially, are complex side effect, and further studies is needed to increase successful exploration and identification of the genetic component and assess contribution. |
| format | Article |
| id | doaj-art-00b33d1e1da1464b8e2a55bc8d3645c7 |
| institution | DOAJ |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-00b33d1e1da1464b8e2a55bc8d3645c72025-08-20T03:20:22ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2019-12-0104-111511710.31363/2313-7053-2019-4-1-115-117307Polymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapyI. V. Pozhidaev0A. S. Boiko1E. G. Kornetova2Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesThe use of atypical antipsychotic drugs has made metabolic disorders one of the most common side effect of pharmacotherapy for schizophrenic patients. The aim of this study was to assess the contribution of polymorphic variants of genes of the P450 cytochrome system to changes in body mass index in patients with schizophrenia. As a result of the study, we did not identify significant associations of genotypes and alleles of the studied polymorphic variants of the CYP2D6, CYP1A2, CYP2C19 genes with weight gain in patients with schizophrenia of Russian nationality of the Siberian region receiving antipsychotic therapy and can revealed neither protective nor predisposing effects. Metabolic syndrome and, increase in body weight especially, are complex side effect, and further studies is needed to increase successful exploration and identification of the genetic component and assess contribution.https://www.bekhterevreview.com/jour/article/view/328schizophrenia, bmi, cytochromes, р450, polymorphic variant |
| spellingShingle | I. V. Pozhidaev A. S. Boiko E. G. Kornetova Polymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapy Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева schizophrenia, bmi, cytochromes, р450, polymorphic variant |
| title | Polymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapy |
| title_full | Polymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapy |
| title_fullStr | Polymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapy |
| title_full_unstemmed | Polymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapy |
| title_short | Polymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapy |
| title_sort | polymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapy |
| topic | schizophrenia, bmi, cytochromes, р450, polymorphic variant |
| url | https://www.bekhterevreview.com/jour/article/view/328 |
| work_keys_str_mv | AT ivpozhidaev polymorphicvariantsofxenobioticmetabolismgenesandbodymassindexinschizophreniapatientsreceivingantipsychotictherapy AT asboiko polymorphicvariantsofxenobioticmetabolismgenesandbodymassindexinschizophreniapatientsreceivingantipsychotictherapy AT egkornetova polymorphicvariantsofxenobioticmetabolismgenesandbodymassindexinschizophreniapatientsreceivingantipsychotictherapy |