Characterization of primary and secondary polycythemia among Palestinian blood donors in the West bank
Abstract Polycythemia is a hematological condition characterized by an elevated red blood cell (RBC) mass that exceeds the normal range for a specific age and gender; it can be classified as either primary or secondary. This study aimed to estimate the prevalence of primary and secondary polycythemi...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-13062-8 |
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| author | Gana Odeh Mohammed Alili Roa Hamshari Ahmad Saabna Rami Zagha Mahmoud Draidi Safa’ Bushnaq Suheir Ereqat Basma Damiri |
| author_facet | Gana Odeh Mohammed Alili Roa Hamshari Ahmad Saabna Rami Zagha Mahmoud Draidi Safa’ Bushnaq Suheir Ereqat Basma Damiri |
| author_sort | Gana Odeh |
| collection | DOAJ |
| description | Abstract Polycythemia is a hematological condition characterized by an elevated red blood cell (RBC) mass that exceeds the normal range for a specific age and gender; it can be classified as either primary or secondary. This study aimed to estimate the prevalence of primary and secondary polycythemia among adult blood donors in the West Bank and characterize potential risk factors. This cross-sectional study included 674 adult Palestinian male blood donors, aged 18 to 62 years, at An-Najah National University Hospital. Data were collected through face-to-face interviews. Eligible donors underwent complete blood count (CBC) analysis, and samples meeting the latest World Health Organization (WHO) diagnostic criteria for polycythemia, hemoglobin > 16.5 g/dL or hematocrit > 49% in men, were sent for DNA sequencing. Among the participants, 16.6% met the diagnostic criteria for polycythemia; however, none had the JAK2 p.V617F mutation, indicating a potential lack of polycythemia vera (PV). Risk factor analysis revealed an increased risk of polycythemia in moderate (p = 0.039, OR 2.223, [95% CI 1.041–4.746]), heavy cigarette smoking (p = 0.008, OR 2.301, [95% CI 1.246–4.249]), and heavy waterpipe smoking (p ≤ 0.001, OR: 5.019, [95% CI 2.364–10.653]), whereas heavy coffee consumption had a protective effect against polycythemia (p = 0.013, OR 0.444 [95% CI 0.234–0.843]). The absence of the JAK2 p.V617F mutation among participants suggests that secondary polycythemia predominance is driven by smoking and other modifiable lifestyle factors. These findings emphasize the importance of public health efforts focused on lifestyle modification to reduce the risk of polycythemia. |
| format | Article |
| id | doaj-art-00af81ed14c04298a7e2936bf1eb0c39 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-00af81ed14c04298a7e2936bf1eb0c392025-08-20T03:45:59ZengNature PortfolioScientific Reports2045-23222025-07-0115111010.1038/s41598-025-13062-8Characterization of primary and secondary polycythemia among Palestinian blood donors in the West bankGana Odeh0Mohammed Alili1Roa Hamshari2Ahmad Saabna3Rami Zagha4Mahmoud Draidi5Safa’ Bushnaq6Suheir Ereqat7Basma Damiri8Department of Medicine, An-Najah National UniversityDepartment of Medicine, An-Najah National UniversityDepartment of Medicine, An-Najah National UniversityDepartment of Medicine, An-Najah National UniversityDepartment of Pathology, Faculty of Medicine and Health Sciences, An-Najah National UniversityDepartment of Medicine, An-Najah National UniversityMolecular Genetics Laboratory, An-Najah National University HospitalBiochemistry and Molecular Biology Department, Faculty of Medicine, Al-Quds UniversityFaculty of Medicine and Health Sciences, Physiology, Pharmacology, and Toxicology Division, An-Najah National UniversityAbstract Polycythemia is a hematological condition characterized by an elevated red blood cell (RBC) mass that exceeds the normal range for a specific age and gender; it can be classified as either primary or secondary. This study aimed to estimate the prevalence of primary and secondary polycythemia among adult blood donors in the West Bank and characterize potential risk factors. This cross-sectional study included 674 adult Palestinian male blood donors, aged 18 to 62 years, at An-Najah National University Hospital. Data were collected through face-to-face interviews. Eligible donors underwent complete blood count (CBC) analysis, and samples meeting the latest World Health Organization (WHO) diagnostic criteria for polycythemia, hemoglobin > 16.5 g/dL or hematocrit > 49% in men, were sent for DNA sequencing. Among the participants, 16.6% met the diagnostic criteria for polycythemia; however, none had the JAK2 p.V617F mutation, indicating a potential lack of polycythemia vera (PV). Risk factor analysis revealed an increased risk of polycythemia in moderate (p = 0.039, OR 2.223, [95% CI 1.041–4.746]), heavy cigarette smoking (p = 0.008, OR 2.301, [95% CI 1.246–4.249]), and heavy waterpipe smoking (p ≤ 0.001, OR: 5.019, [95% CI 2.364–10.653]), whereas heavy coffee consumption had a protective effect against polycythemia (p = 0.013, OR 0.444 [95% CI 0.234–0.843]). The absence of the JAK2 p.V617F mutation among participants suggests that secondary polycythemia predominance is driven by smoking and other modifiable lifestyle factors. These findings emphasize the importance of public health efforts focused on lifestyle modification to reduce the risk of polycythemia.https://doi.org/10.1038/s41598-025-13062-8PolycythemiaJAK2 mutationBlood donationHemoglobinTobacco smokingWest bank |
| spellingShingle | Gana Odeh Mohammed Alili Roa Hamshari Ahmad Saabna Rami Zagha Mahmoud Draidi Safa’ Bushnaq Suheir Ereqat Basma Damiri Characterization of primary and secondary polycythemia among Palestinian blood donors in the West bank Scientific Reports Polycythemia JAK2 mutation Blood donation Hemoglobin Tobacco smoking West bank |
| title | Characterization of primary and secondary polycythemia among Palestinian blood donors in the West bank |
| title_full | Characterization of primary and secondary polycythemia among Palestinian blood donors in the West bank |
| title_fullStr | Characterization of primary and secondary polycythemia among Palestinian blood donors in the West bank |
| title_full_unstemmed | Characterization of primary and secondary polycythemia among Palestinian blood donors in the West bank |
| title_short | Characterization of primary and secondary polycythemia among Palestinian blood donors in the West bank |
| title_sort | characterization of primary and secondary polycythemia among palestinian blood donors in the west bank |
| topic | Polycythemia JAK2 mutation Blood donation Hemoglobin Tobacco smoking West bank |
| url | https://doi.org/10.1038/s41598-025-13062-8 |
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