Effect of enhanced external counterpulsation versus individual shear rate therapy on the peripheral artery functions
Abstract In this study, we aimed to assess the effects of enhanced external counterpulsation (EECP) and individual shear rate therapy (ISRT) on peripheral artery function in patients with lower extremity atherosclerotic disease (LEAD). We randomly assigned 45 LEAD patients to receive 35 sessions of...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-82485-6 |
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| author | Yahui Zhang Yujia Zhang Chubin Zhong Yaqin Wang Wenbin Wei Guifu Wu |
| author_facet | Yahui Zhang Yujia Zhang Chubin Zhong Yaqin Wang Wenbin Wei Guifu Wu |
| author_sort | Yahui Zhang |
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| description | Abstract In this study, we aimed to assess the effects of enhanced external counterpulsation (EECP) and individual shear rate therapy (ISRT) on peripheral artery function in patients with lower extremity atherosclerotic disease (LEAD). We randomly assigned 45 LEAD patients to receive 35 sessions of 45 min of EECP (n = 15), ISRT (n = 15), or sham-control (n = 15). Flow-mediated dilation in the brachial artery (brachial-FMD); 6-min walk distance; blood flow in the popliteal, posterior tibial, anterior tibial, and dorsalis pedis arteries; and plasma levels were measured before and after the 7 weeks treatment. 36-item Short Form Health Survey [SF-36] was analyzed before, after 7 weeks, and 3-month follow-ups. EECP treatment significantly improved brachial-FMD and quality of life, increased walking distance, and increased blood flow and the diameters of the popliteal artery and posterior tibial artery (all P < 0.01). Conversely, ISRT markedly increased blood flow in the anterior tibial artery (P < 0.05). EECP and ISRT decreased the endothelin-1 and asymmetrical dimethylarginine levels in patients with LEAD (both P < 0.01). Additionally, sVCAM-1 was significantly reduced after EECP intervention (P = 0.004). Our findings demonstrate that EECP and ISRT have beneficial effects on walking distance, quality of life, flow-mediated dilation, endothelial-derived vasoactive agents, and inflammatory and oxidative stress in LEAD patients. Date of registration: 2021-06-21. Trial registration: ChiCTR2100048086. |
| format | Article |
| id | doaj-art-00a8ba62aceb45ef8eaca7a1cfc3d1ec |
| institution | DOAJ |
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| publishDate | 2024-12-01 |
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| spelling | doaj-art-00a8ba62aceb45ef8eaca7a1cfc3d1ec2025-08-20T02:43:33ZengNature PortfolioScientific Reports2045-23222024-12-0114111410.1038/s41598-024-82485-6Effect of enhanced external counterpulsation versus individual shear rate therapy on the peripheral artery functionsYahui Zhang0Yujia Zhang1Chubin Zhong2Yaqin Wang3Wenbin Wei4Guifu Wu5Department of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen UniversityDepartment of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen UniversityDepartment of Cardiac Ultrasound, The Eighth Affiliated Hospital, Sun Yat-sen UniversitySchool of Health and Life Sciences, University of Health and Rehabilitation SciencesDepartment of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen UniversityDepartment of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen UniversityAbstract In this study, we aimed to assess the effects of enhanced external counterpulsation (EECP) and individual shear rate therapy (ISRT) on peripheral artery function in patients with lower extremity atherosclerotic disease (LEAD). We randomly assigned 45 LEAD patients to receive 35 sessions of 45 min of EECP (n = 15), ISRT (n = 15), or sham-control (n = 15). Flow-mediated dilation in the brachial artery (brachial-FMD); 6-min walk distance; blood flow in the popliteal, posterior tibial, anterior tibial, and dorsalis pedis arteries; and plasma levels were measured before and after the 7 weeks treatment. 36-item Short Form Health Survey [SF-36] was analyzed before, after 7 weeks, and 3-month follow-ups. EECP treatment significantly improved brachial-FMD and quality of life, increased walking distance, and increased blood flow and the diameters of the popliteal artery and posterior tibial artery (all P < 0.01). Conversely, ISRT markedly increased blood flow in the anterior tibial artery (P < 0.05). EECP and ISRT decreased the endothelin-1 and asymmetrical dimethylarginine levels in patients with LEAD (both P < 0.01). Additionally, sVCAM-1 was significantly reduced after EECP intervention (P = 0.004). Our findings demonstrate that EECP and ISRT have beneficial effects on walking distance, quality of life, flow-mediated dilation, endothelial-derived vasoactive agents, and inflammatory and oxidative stress in LEAD patients. Date of registration: 2021-06-21. Trial registration: ChiCTR2100048086.https://doi.org/10.1038/s41598-024-82485-6Enhanced external counterpulsationIndividual shear rate therapyLower extremity atherosclerotic diseaseVascular hemodynamicsWalking distance |
| spellingShingle | Yahui Zhang Yujia Zhang Chubin Zhong Yaqin Wang Wenbin Wei Guifu Wu Effect of enhanced external counterpulsation versus individual shear rate therapy on the peripheral artery functions Scientific Reports Enhanced external counterpulsation Individual shear rate therapy Lower extremity atherosclerotic disease Vascular hemodynamics Walking distance |
| title | Effect of enhanced external counterpulsation versus individual shear rate therapy on the peripheral artery functions |
| title_full | Effect of enhanced external counterpulsation versus individual shear rate therapy on the peripheral artery functions |
| title_fullStr | Effect of enhanced external counterpulsation versus individual shear rate therapy on the peripheral artery functions |
| title_full_unstemmed | Effect of enhanced external counterpulsation versus individual shear rate therapy on the peripheral artery functions |
| title_short | Effect of enhanced external counterpulsation versus individual shear rate therapy on the peripheral artery functions |
| title_sort | effect of enhanced external counterpulsation versus individual shear rate therapy on the peripheral artery functions |
| topic | Enhanced external counterpulsation Individual shear rate therapy Lower extremity atherosclerotic disease Vascular hemodynamics Walking distance |
| url | https://doi.org/10.1038/s41598-024-82485-6 |
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