Non-immunogenic staphylokinase in the treatment of high-risk massive pulmonary embolism in the early postoperative period due to femoral fragment wound
A case report of double thrombolytic therapy with non-immunogenic staphylokinase at a dose of 15 mg bolus over 15 s in a patient with a high-risk massive pulmonary embolism (PE) in the early postoperative period due to femoral wound is described. After the second thrombolysis, a decrease in the pulm...
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| Format: | Article |
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Столичная издательская компания
2023-11-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/2957 |
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| author | S. L. Konstantinov G. I. Stryabkova A. I. Basarab V. N. Kravchuk I. V. Kаzhanov S. V. Ivanov Zh. Yu. Chefranova S. S. Markin |
| author_facet | S. L. Konstantinov G. I. Stryabkova A. I. Basarab V. N. Kravchuk I. V. Kаzhanov S. V. Ivanov Zh. Yu. Chefranova S. S. Markin |
| author_sort | S. L. Konstantinov |
| collection | DOAJ |
| description | A case report of double thrombolytic therapy with non-immunogenic staphylokinase at a dose of 15 mg bolus over 15 s in a patient with a high-risk massive pulmonary embolism (PE) in the early postoperative period due to femoral wound is described. After the second thrombolysis, a decrease in the pulmonary arteries thrombotic lesions according to multislice computed tomography data, restoration of right ventricular function, and a decrease in pulmonary hypertension were observed. Reuse of the non-immunogenic staphylokinase did not lead to the major bleeding and hemorrhagic stroke, did not provoke a drop in hemoglobin and did not require blood transfusion. Upon discharge of the patient, normalization of the general blood test parameters was noted: the level of hemoglobin increased from 86 to 112 g/l, erythrocytes — from 2.8 to 3.5x1012/l, hematocrit — from 26 to 32%. Thus, non-immunogenic staphylokinase has demonstrated high efficacy and safety in the treatment of patient with a high-risk massive PE in the early postoperative period. |
| format | Article |
| id | doaj-art-00a80b5d525a478184b93f381c75a380 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-00a80b5d525a478184b93f381c75a3802025-08-23T10:00:36ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532023-11-0119549550110.20996/1819-6446-2023-29572154Non-immunogenic staphylokinase in the treatment of high-risk massive pulmonary embolism in the early postoperative period due to femoral fragment woundS. L. Konstantinov0G. I. Stryabkova1A. I. Basarab2V. N. Kravchuk3I. V. Kаzhanov4S. V. Ivanov5Zh. Yu. Chefranova6S. S. Markin7Belgorod Regional Clinical Hospital of St. JosephBelgorod Regional Clinical Hospital of St. JosephBelgorod Regional Clinical Hospital of St. JosephMilitary Medical Academy named after S.M. Kirov; North-Western State Medical University named after I.I. MechnikovMilitary Medical Academy named after S.M. Kirov; I.P. Pavlov First Saint Petersburg State Medical University; I.I. Dzhanelidze Saint Petersburg Research Institute of Emergency MedicineInstitute of Biomedical ChemistryBelgorod Regional Clinical Hospital of St. JosephInstitute of Biomedical ChemistryA case report of double thrombolytic therapy with non-immunogenic staphylokinase at a dose of 15 mg bolus over 15 s in a patient with a high-risk massive pulmonary embolism (PE) in the early postoperative period due to femoral wound is described. After the second thrombolysis, a decrease in the pulmonary arteries thrombotic lesions according to multislice computed tomography data, restoration of right ventricular function, and a decrease in pulmonary hypertension were observed. Reuse of the non-immunogenic staphylokinase did not lead to the major bleeding and hemorrhagic stroke, did not provoke a drop in hemoglobin and did not require blood transfusion. Upon discharge of the patient, normalization of the general blood test parameters was noted: the level of hemoglobin increased from 86 to 112 g/l, erythrocytes — from 2.8 to 3.5x1012/l, hematocrit — from 26 to 32%. Thus, non-immunogenic staphylokinase has demonstrated high efficacy and safety in the treatment of patient with a high-risk massive PE in the early postoperative period.https://www.rpcardio.online/jour/article/view/2957non-immunogenic staphylokinasepulmonary embolismpostoperative periodrisk of bleeding |
| spellingShingle | S. L. Konstantinov G. I. Stryabkova A. I. Basarab V. N. Kravchuk I. V. Kаzhanov S. V. Ivanov Zh. Yu. Chefranova S. S. Markin Non-immunogenic staphylokinase in the treatment of high-risk massive pulmonary embolism in the early postoperative period due to femoral fragment wound Рациональная фармакотерапия в кардиологии non-immunogenic staphylokinase pulmonary embolism postoperative period risk of bleeding |
| title | Non-immunogenic staphylokinase in the treatment of high-risk massive pulmonary embolism in the early postoperative period due to femoral fragment wound |
| title_full | Non-immunogenic staphylokinase in the treatment of high-risk massive pulmonary embolism in the early postoperative period due to femoral fragment wound |
| title_fullStr | Non-immunogenic staphylokinase in the treatment of high-risk massive pulmonary embolism in the early postoperative period due to femoral fragment wound |
| title_full_unstemmed | Non-immunogenic staphylokinase in the treatment of high-risk massive pulmonary embolism in the early postoperative period due to femoral fragment wound |
| title_short | Non-immunogenic staphylokinase in the treatment of high-risk massive pulmonary embolism in the early postoperative period due to femoral fragment wound |
| title_sort | non immunogenic staphylokinase in the treatment of high risk massive pulmonary embolism in the early postoperative period due to femoral fragment wound |
| topic | non-immunogenic staphylokinase pulmonary embolism postoperative period risk of bleeding |
| url | https://www.rpcardio.online/jour/article/view/2957 |
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