Contextual responses drive a unique laminar signature in human V1
Summary: Neuronal populations in visual cortex integrate stimulus-driven input from the retina with contextual input from neighboring neurons, each targeting distinct cortical layers. Using line-scanning fMRI with precise targeting, we recorded depth-resolved responses in human visual cortex to stim...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225012283 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849426247513276416 |
|---|---|
| author | Jurjen Heij Luisa Raimondo Jeroen C.W. Siero Wietske van der Zwaag Tomas Knapen Serge O. Dumoulin |
| author_facet | Jurjen Heij Luisa Raimondo Jeroen C.W. Siero Wietske van der Zwaag Tomas Knapen Serge O. Dumoulin |
| author_sort | Jurjen Heij |
| collection | DOAJ |
| description | Summary: Neuronal populations in visual cortex integrate stimulus-driven input from the retina with contextual input from neighboring neurons, each targeting distinct cortical layers. Using line-scanning fMRI with precise targeting, we recorded depth-resolved responses in human visual cortex to stimuli tailored to each participant’s population receptive field (pRF) of the target patch. Stimuli in the center of the pRF evoked increasing responses toward the pial surface with a small peak at middle depths, consistent with feedforward input. Large stimuli in the surround elicited activity in superficial and deep layers, where descending connections terminate. Unexpectedly, medium-sized stimuli produced a complex pattern, possibly due to overlap from neuronal populations involved in stimulus- and context-related processes. Additionally, large surround stimuli evoked a negative deflection at middle depths, potentially reflecting suppression from lateral inhibitory circuits. These findings bridge invasive animal studies with human neuroimaging and highlight the potential for manipulating cortical computations non-invasively in cognitive neuroscience. |
| format | Article |
| id | doaj-art-00a6b24f18c24ee7b8f3782680ca7d5c |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-00a6b24f18c24ee7b8f3782680ca7d5c2025-08-20T03:29:31ZengElsevieriScience2589-00422025-07-0128711296710.1016/j.isci.2025.112967Contextual responses drive a unique laminar signature in human V1Jurjen Heij0Luisa Raimondo1Jeroen C.W. Siero2Wietske van der Zwaag3Tomas Knapen4Serge O. Dumoulin5Spinoza Centre for Neuroimaging, Amsterdam, the Netherlands; Department of Computational Cognitive Neuroscience and Neuroimaging, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands; Department of Experimental and Applied Psychology, VU University, Amsterdam, the Netherlands; Corresponding authorSpinoza Centre for Neuroimaging, Amsterdam, the Netherlands; Department of Computational Cognitive Neuroscience and Neuroimaging, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands; Department of Experimental and Applied Psychology, VU University, Amsterdam, the NetherlandsSpinoza Centre for Neuroimaging, Amsterdam, the Netherlands; Department of Computational Cognitive Neuroscience and Neuroimaging, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands; Department of Radiology, Center for Image Sciences, University Medical Center Utrecht, Utrecht, the NetherlandsSpinoza Centre for Neuroimaging, Amsterdam, the Netherlands; Department of Computational Cognitive Neuroscience and Neuroimaging, Netherlands Institute for Neuroscience, Amsterdam, the NetherlandsSpinoza Centre for Neuroimaging, Amsterdam, the Netherlands; Department of Computational Cognitive Neuroscience and Neuroimaging, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands; Department of Experimental and Applied Psychology, VU University, Amsterdam, the NetherlandsSpinoza Centre for Neuroimaging, Amsterdam, the Netherlands; Department of Computational Cognitive Neuroscience and Neuroimaging, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands; Department of Experimental and Applied Psychology, VU University, Amsterdam, the Netherlands; Department of Experimental Psychology, Utrecht University, Utrecht, the NetherlandsSummary: Neuronal populations in visual cortex integrate stimulus-driven input from the retina with contextual input from neighboring neurons, each targeting distinct cortical layers. Using line-scanning fMRI with precise targeting, we recorded depth-resolved responses in human visual cortex to stimuli tailored to each participant’s population receptive field (pRF) of the target patch. Stimuli in the center of the pRF evoked increasing responses toward the pial surface with a small peak at middle depths, consistent with feedforward input. Large stimuli in the surround elicited activity in superficial and deep layers, where descending connections terminate. Unexpectedly, medium-sized stimuli produced a complex pattern, possibly due to overlap from neuronal populations involved in stimulus- and context-related processes. Additionally, large surround stimuli evoked a negative deflection at middle depths, potentially reflecting suppression from lateral inhibitory circuits. These findings bridge invasive animal studies with human neuroimaging and highlight the potential for manipulating cortical computations non-invasively in cognitive neuroscience.http://www.sciencedirect.com/science/article/pii/S2589004225012283Natural sciencesBiological sciencesNeuroscienceSystems neuroscience |
| spellingShingle | Jurjen Heij Luisa Raimondo Jeroen C.W. Siero Wietske van der Zwaag Tomas Knapen Serge O. Dumoulin Contextual responses drive a unique laminar signature in human V1 iScience Natural sciences Biological sciences Neuroscience Systems neuroscience |
| title | Contextual responses drive a unique laminar signature in human V1 |
| title_full | Contextual responses drive a unique laminar signature in human V1 |
| title_fullStr | Contextual responses drive a unique laminar signature in human V1 |
| title_full_unstemmed | Contextual responses drive a unique laminar signature in human V1 |
| title_short | Contextual responses drive a unique laminar signature in human V1 |
| title_sort | contextual responses drive a unique laminar signature in human v1 |
| topic | Natural sciences Biological sciences Neuroscience Systems neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225012283 |
| work_keys_str_mv | AT jurjenheij contextualresponsesdriveauniquelaminarsignatureinhumanv1 AT luisaraimondo contextualresponsesdriveauniquelaminarsignatureinhumanv1 AT jeroencwsiero contextualresponsesdriveauniquelaminarsignatureinhumanv1 AT wietskevanderzwaag contextualresponsesdriveauniquelaminarsignatureinhumanv1 AT tomasknapen contextualresponsesdriveauniquelaminarsignatureinhumanv1 AT sergeodumoulin contextualresponsesdriveauniquelaminarsignatureinhumanv1 |