Comparison of efficacy and toxicity of FC and FCR regimens in primary B-cell chronic lymphocytic leukemia: a retrospective study
Preclinical studies showed synergic anti-tumor activity of Rituximab and Fludarabin. Comparison of efficacy of FC with FCR regimens administered in first line therapy and their influence on disease-free and overall survival in patients with B-cell lymphocytic leukemia were the main goals of this ret...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2022-11-01
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| Series: | Онкогематология |
| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/679 |
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| author | Ye. А. Stadnik Ye. А. Nikitin B. V. Biderman G. N. Salogub Yu. Yu. Lorie N. N. Tsyba Yu. A. Alexeeva V. A. Doronin V. N. Mashuk R. I. Vabishevich A. L. Melikyan T. I. Kolosheinova L. Yu. Kolosova A. B. Sudarikov L. G. Kovaleva A. Yu. Zaritsky |
| author_facet | Ye. А. Stadnik Ye. А. Nikitin B. V. Biderman G. N. Salogub Yu. Yu. Lorie N. N. Tsyba Yu. A. Alexeeva V. A. Doronin V. N. Mashuk R. I. Vabishevich A. L. Melikyan T. I. Kolosheinova L. Yu. Kolosova A. B. Sudarikov L. G. Kovaleva A. Yu. Zaritsky |
| author_sort | Ye. А. Stadnik |
| collection | DOAJ |
| description | Preclinical studies showed synergic anti-tumor activity of Rituximab and Fludarabin. Comparison of efficacy of FC with FCR regimens administered in first line therapy and their influence on disease-free and overall survival in patients with B-cell lymphocytic leukemia were the main goals of this retrospective study. It has been demonstrated that inclusion of Rituximab into the FC regimen improves outcome of patients with B-cell lymphocytic leukemia without significant increase of toxicity. |
| format | Article |
| id | doaj-art-00a0c2ea06324c9092c0197da79d94d1 |
| institution | DOAJ |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2022-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-00a0c2ea06324c9092c0197da79d94d12025-08-20T03:01:06ZrusABV-pressОнкогематология1818-83462413-40232022-11-0101-2394610.17650/1818-8346-2008-0-1-2-39-46557Comparison of efficacy and toxicity of FC and FCR regimens in primary B-cell chronic lymphocytic leukemia: a retrospective studyYe. А. Stadnik0Ye. А. Nikitin1B. V. Biderman2G. N. Salogub3Yu. Yu. Lorie4N. N. Tsyba5Yu. A. Alexeeva6V. A. Doronin7V. N. Mashuk8R. I. Vabishevich9A. L. Melikyan10T. I. Kolosheinova11L. Yu. Kolosova12A. B. Sudarikov13L. G. Kovaleva14A. Yu. Zaritsky15Городская клиническая больница №31ГУ «Гематологический научный центр» РАМНГУ «Гематологический научный центр» РАМНГородская клиническая больница №31ГУ «Гематологический научный центр» РАМНГУ «Гематологический научный центр» РАМНГородская клиническая больница №31Центральная клиническая больница №2 Министерства путей сообщенияКраснодарский краевой онкодиспансерФедеральный центр крови, сердца и эндокринологии им. акад. В.А. АлмазоваГУ «Гематологический научный центр» РАМНГУ «Гематологический научный центр» РАМНГУ «Гематологический научный центр» РАМНГУ «Гематологический научный центр» РАМНГУ «Гематологический научный центр» РАМНФедеральный центр крови, сердца и эндокринологии им. акад. В.А. АлмазоваPreclinical studies showed synergic anti-tumor activity of Rituximab and Fludarabin. Comparison of efficacy of FC with FCR regimens administered in first line therapy and their influence on disease-free and overall survival in patients with B-cell lymphocytic leukemia were the main goals of this retrospective study. It has been demonstrated that inclusion of Rituximab into the FC regimen improves outcome of patients with B-cell lymphocytic leukemia without significant increase of toxicity.https://oncohematology.abvpress.ru/ongm/article/view/679 |
| spellingShingle | Ye. А. Stadnik Ye. А. Nikitin B. V. Biderman G. N. Salogub Yu. Yu. Lorie N. N. Tsyba Yu. A. Alexeeva V. A. Doronin V. N. Mashuk R. I. Vabishevich A. L. Melikyan T. I. Kolosheinova L. Yu. Kolosova A. B. Sudarikov L. G. Kovaleva A. Yu. Zaritsky Comparison of efficacy and toxicity of FC and FCR regimens in primary B-cell chronic lymphocytic leukemia: a retrospective study Онкогематология |
| title | Comparison of efficacy and toxicity of FC and FCR regimens in primary B-cell chronic lymphocytic leukemia: a retrospective study |
| title_full | Comparison of efficacy and toxicity of FC and FCR regimens in primary B-cell chronic lymphocytic leukemia: a retrospective study |
| title_fullStr | Comparison of efficacy and toxicity of FC and FCR regimens in primary B-cell chronic lymphocytic leukemia: a retrospective study |
| title_full_unstemmed | Comparison of efficacy and toxicity of FC and FCR regimens in primary B-cell chronic lymphocytic leukemia: a retrospective study |
| title_short | Comparison of efficacy and toxicity of FC and FCR regimens in primary B-cell chronic lymphocytic leukemia: a retrospective study |
| title_sort | comparison of efficacy and toxicity of fc and fcr regimens in primary b cell chronic lymphocytic leukemia a retrospective study |
| url | https://oncohematology.abvpress.ru/ongm/article/view/679 |
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