PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway
Background. Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damage in IR injury. Aim. In this study, we explored the potentia...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6626295 |
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| _version_ | 1850237340691202048 |
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| author | Liwei Wu Qiang Yu Ping Cheng Chuanyong Guo |
| author_facet | Liwei Wu Qiang Yu Ping Cheng Chuanyong Guo |
| author_sort | Liwei Wu |
| collection | DOAJ |
| description | Background. Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damage in IR injury. Aim. In this study, we explored the potential mechanism of PPARγ in the pathogenesis of hepatic IR injury by mice model. Methods. After treated with si-PPARγ or rosiglitazone, mice were subjected to hepatic ischemia-reperfusion. Liver tissue and blood samples were collected to evaluate liver injury and detected relative mRNA and protein expressions. Results. The expression of PPARγ was increased after reperfusion. And the alleviation of PPARγ aggravated the liver damage in IR; at the same time, upregulation of the expression of PPARγ released the liver damage. And these effects of PPARγ in IR were related to the AMPK/mTOR/autophagy signaling pathway. Conclusion. PPARγ plays an important role in hepatic IR injury at least partly via the AMPK/mTOR/autophagy pathway. |
| format | Article |
| id | doaj-art-009d8a7d19b44987bcb6e61d91e3e72d |
| institution | OA Journals |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-009d8a7d19b44987bcb6e61d91e3e72d2025-08-20T02:01:46ZengWileyPPAR Research1687-47571687-47652021-01-01202110.1155/2021/66262956626295PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR PathwayLiwei Wu0Qiang Yu1Ping Cheng2Chuanyong Guo3Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Gerontology, Shanghai Minhang District Central Hospital, Shanghai 201100, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaBackground. Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damage in IR injury. Aim. In this study, we explored the potential mechanism of PPARγ in the pathogenesis of hepatic IR injury by mice model. Methods. After treated with si-PPARγ or rosiglitazone, mice were subjected to hepatic ischemia-reperfusion. Liver tissue and blood samples were collected to evaluate liver injury and detected relative mRNA and protein expressions. Results. The expression of PPARγ was increased after reperfusion. And the alleviation of PPARγ aggravated the liver damage in IR; at the same time, upregulation of the expression of PPARγ released the liver damage. And these effects of PPARγ in IR were related to the AMPK/mTOR/autophagy signaling pathway. Conclusion. PPARγ plays an important role in hepatic IR injury at least partly via the AMPK/mTOR/autophagy pathway.http://dx.doi.org/10.1155/2021/6626295 |
| spellingShingle | Liwei Wu Qiang Yu Ping Cheng Chuanyong Guo PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway PPAR Research |
| title | PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway |
| title_full | PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway |
| title_fullStr | PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway |
| title_full_unstemmed | PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway |
| title_short | PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway |
| title_sort | pparγ plays an important role in acute hepatic ischemia reperfusion injury via ampk mtor pathway |
| url | http://dx.doi.org/10.1155/2021/6626295 |
| work_keys_str_mv | AT liweiwu ppargplaysanimportantroleinacutehepaticischemiareperfusioninjuryviaampkmtorpathway AT qiangyu ppargplaysanimportantroleinacutehepaticischemiareperfusioninjuryviaampkmtorpathway AT pingcheng ppargplaysanimportantroleinacutehepaticischemiareperfusioninjuryviaampkmtorpathway AT chuanyongguo ppargplaysanimportantroleinacutehepaticischemiareperfusioninjuryviaampkmtorpathway |