Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans

Background: Aging can be understood as a consequence of the declining force of natural selection with age. Consistent with this, the antagonistic pleiotropy theory of aging proposes that aging arises from trade-offs that favor early growth and reproduction. However, evidence supporting antagonistic...

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Main Authors: Yifan Xiang, Vineeta Tanwar, Parminder Singh, Lizellen La Follette, Vikram Pratap Narayan, Pankaj Kapahi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-08-01
Series:eLife
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Online Access:https://elifesciences.org/articles/102447
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