Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes
Background. Previous studies have suggested the existence of distinct body size subgroups according to metabolic health referred to as metabolically healthy obesity (MHO) and metabolically abnormal but normal weight (MANW) patients. Although nonalcoholic fatty liver disease (NAFLD) is strongly assoc...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/7918714 |
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| author | Hye Soo Chung Hyun Jung Lee Soon Young Hwang Ju-Hee Choi Hye Jin Yoo Ji A. Seo Sin Gon Kim Nan Hee Kim Dong Seop Choi Sei Hyun Baik Kyung Mook Choi |
| author_facet | Hye Soo Chung Hyun Jung Lee Soon Young Hwang Ju-Hee Choi Hye Jin Yoo Ji A. Seo Sin Gon Kim Nan Hee Kim Dong Seop Choi Sei Hyun Baik Kyung Mook Choi |
| author_sort | Hye Soo Chung |
| collection | DOAJ |
| description | Background. Previous studies have suggested the existence of distinct body size subgroups according to metabolic health referred to as metabolically healthy obesity (MHO) and metabolically abnormal but normal weight (MANW) patients. Although nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and metabolic syndrome, the relationship between these phenotypes and fetuin-A, a representative hepatokine, has not been explored. Methods. We examined the association between circulating fetuin-A levels, metabolic health phenotypes, cardiometabolic risk parameters, and subclinical atherosclerosis in 290 subjects who were randomly selected from an ongoing cohort study. Results. Fetuin-A concentrations were significantly associated with detrimental anthropometric and laboratory measurements, including increased waist circumference, blood pressure, alanine aminotransferase, fasting plasma glucose, and triglyceride levels. Furthermore, fetuin-A levels were significantly increased in the metabolically abnormal (MA) group compared to the metabolically healthy (MH) group in subjects without obesity (717.1 [632.1, 769.7] vs. 599.5 [502.0, 709.3], P=0.001) and subjects with obesity (704.1 [595.5-880.9] vs. 612.2 [547.9-802.1], P=0.016). In addition, brachial-ankle pulse wave velocity (baPWV), which reflects arterial stiffness, was higher in MA individuals compared to MH individuals. Multiple logistic regression analysis revealed that both individuals without obesity (P for trend = 0.017) and with obesity (P for trend = 0.028) in the higher tertiles of fetuin-A had an increased risk of MA than those in the lowest tertile. Conclusions. This study demonstrates that fetuin-A levels are significantly associated with metabolic health phenotypes, such as MHO and MANW, in Korean adults. |
| format | Article |
| id | doaj-art-0094b8b187e9435aaf9513900005ebc4 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-0094b8b187e9435aaf9513900005ebc42025-02-03T07:24:04ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/79187147918714Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic PhenotypesHye Soo Chung0Hyun Jung Lee1Soon Young Hwang2Ju-Hee Choi3Hye Jin Yoo4Ji A. Seo5Sin Gon Kim6Nan Hee Kim7Dong Seop Choi8Sei Hyun Baik9Kyung Mook Choi10Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of KoreaDepartment of Biostatistics, College of Medicine, Korea University, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of KoreaBackground. Previous studies have suggested the existence of distinct body size subgroups according to metabolic health referred to as metabolically healthy obesity (MHO) and metabolically abnormal but normal weight (MANW) patients. Although nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and metabolic syndrome, the relationship between these phenotypes and fetuin-A, a representative hepatokine, has not been explored. Methods. We examined the association between circulating fetuin-A levels, metabolic health phenotypes, cardiometabolic risk parameters, and subclinical atherosclerosis in 290 subjects who were randomly selected from an ongoing cohort study. Results. Fetuin-A concentrations were significantly associated with detrimental anthropometric and laboratory measurements, including increased waist circumference, blood pressure, alanine aminotransferase, fasting plasma glucose, and triglyceride levels. Furthermore, fetuin-A levels were significantly increased in the metabolically abnormal (MA) group compared to the metabolically healthy (MH) group in subjects without obesity (717.1 [632.1, 769.7] vs. 599.5 [502.0, 709.3], P=0.001) and subjects with obesity (704.1 [595.5-880.9] vs. 612.2 [547.9-802.1], P=0.016). In addition, brachial-ankle pulse wave velocity (baPWV), which reflects arterial stiffness, was higher in MA individuals compared to MH individuals. Multiple logistic regression analysis revealed that both individuals without obesity (P for trend = 0.017) and with obesity (P for trend = 0.028) in the higher tertiles of fetuin-A had an increased risk of MA than those in the lowest tertile. Conclusions. This study demonstrates that fetuin-A levels are significantly associated with metabolic health phenotypes, such as MHO and MANW, in Korean adults.http://dx.doi.org/10.1155/2018/7918714 |
| spellingShingle | Hye Soo Chung Hyun Jung Lee Soon Young Hwang Ju-Hee Choi Hye Jin Yoo Ji A. Seo Sin Gon Kim Nan Hee Kim Dong Seop Choi Sei Hyun Baik Kyung Mook Choi Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes International Journal of Endocrinology |
| title | Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes |
| title_full | Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes |
| title_fullStr | Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes |
| title_full_unstemmed | Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes |
| title_short | Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes |
| title_sort | relationship of circulating fetuin a levels with body size and metabolic phenotypes |
| url | http://dx.doi.org/10.1155/2018/7918714 |
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