Effect of Covishieldtm (AZD1222) Vaccination on Incidences and Severity of Covid-19 among Health-Care Workers
Introduction: Limited information is available regarding effect of vaccination on protection against Covid-19 infections and their severity as well. Objectives: In the present study, we assessed the effect of Covid-19 vaccination on incidences and severity of break through Covid-19 infections. Metho...
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| Format: | Article |
| Language: | Indonesian |
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Universitas Airlangga
2024-08-01
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| Series: | The Indonesian Journal of Occupational Safety and Health |
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| Online Access: | https://e-journal.unair.ac.id/IJOSH/article/view/45637 |
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| author | Alka Verma Amit Goel Priyank Yadav Awale Rupali Bhalchandra Dheeraj Khetan Om P Sanjeev Mallikarjun Gunjiganvi |
| author_facet | Alka Verma Amit Goel Priyank Yadav Awale Rupali Bhalchandra Dheeraj Khetan Om P Sanjeev Mallikarjun Gunjiganvi |
| author_sort | Alka Verma |
| collection | DOAJ |
| description | Introduction: Limited information is available regarding effect of vaccination on protection against Covid-19 infections and their severity as well. Objectives: In the present study, we assessed the effect of Covid-19 vaccination on incidences and severity of break through Covid-19 infections. Method: This retrospective study was conducted at a tertiary care center in Northern India during one calendar year, 1st August 2021 to 31st July 2022. The study population included Health-care workers (HCWs) who were treated for Covid 19 infection and had already received at least 1 dose of Covishield TM (AZD1222) Covid-19 vaccine. Results: Out of 1868 health care workers enrolled for the study, 513 contracted Covid-19 infections. Amongst infected HCWs, number of single and double doses of CovishieldTM (AZD1222) recipients were 112 and 401 respectively. Out of the 513 covid positive HCWs, 459 (89.4%) had mild disease, whereas 54 (10.6%) had moderate disease. None of the HCWs developed severe disease and no mortality was noted in either group. Conclusion: In this study, we found that immunization with two doses of CovishieldTM (AZD1222) vaccine was associated with decline in number of cases with moderate or severe Covid-19. Moreover, immunization with even single dose of CovishieldTM (AZD1222) vaccine prevented development of severe disease. Henceforth, it is concluded that although, immunization with CovishieldTM (AZD1222) could not protect all recipients from SARS-Cov-2 infection, it did prevent the progress of disease to severe grades. |
| format | Article |
| id | doaj-art-00905e10e005463ba61f532dbfc00dc0 |
| institution | OA Journals |
| issn | 2301-8046 2540-7872 |
| language | Indonesian |
| publishDate | 2024-08-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | The Indonesian Journal of Occupational Safety and Health |
| spelling | doaj-art-00905e10e005463ba61f532dbfc00dc02025-08-20T01:55:27ZindUniversitas AirlanggaThe Indonesian Journal of Occupational Safety and Health2301-80462540-78722024-08-0113222222810.20473/ijosh.v13i2.2024.222-22843722Effect of Covishieldtm (AZD1222) Vaccination on Incidences and Severity of Covid-19 among Health-Care WorkersAlka Verma0Amit Goel1Priyank Yadav2Awale Rupali Bhalchandra3https://orcid.org/0000-0001-6149-8330Dheeraj Khetan4https://orcid.org/0000-0002-1807-2390Om P Sanjeev5https://orcid.org/0000-0002-3041-3514Mallikarjun Gunjiganvi6https://orcid.org/0000-0002-0848-3823Emergency Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, LucknowHepatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, LucknowUrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, LucknowLab Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, LucknowTransfusion Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, LucknowEmergency Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, LucknowGeneral Surgery, AIIMS MangalagiriIntroduction: Limited information is available regarding effect of vaccination on protection against Covid-19 infections and their severity as well. Objectives: In the present study, we assessed the effect of Covid-19 vaccination on incidences and severity of break through Covid-19 infections. Method: This retrospective study was conducted at a tertiary care center in Northern India during one calendar year, 1st August 2021 to 31st July 2022. The study population included Health-care workers (HCWs) who were treated for Covid 19 infection and had already received at least 1 dose of Covishield TM (AZD1222) Covid-19 vaccine. Results: Out of 1868 health care workers enrolled for the study, 513 contracted Covid-19 infections. Amongst infected HCWs, number of single and double doses of CovishieldTM (AZD1222) recipients were 112 and 401 respectively. Out of the 513 covid positive HCWs, 459 (89.4%) had mild disease, whereas 54 (10.6%) had moderate disease. None of the HCWs developed severe disease and no mortality was noted in either group. Conclusion: In this study, we found that immunization with two doses of CovishieldTM (AZD1222) vaccine was associated with decline in number of cases with moderate or severe Covid-19. Moreover, immunization with even single dose of CovishieldTM (AZD1222) vaccine prevented development of severe disease. Henceforth, it is concluded that although, immunization with CovishieldTM (AZD1222) could not protect all recipients from SARS-Cov-2 infection, it did prevent the progress of disease to severe grades.https://e-journal.unair.ac.id/IJOSH/article/view/45637abo blood group,coronavirus infectioncovid-19critical careintubationmortalityseverity |
| spellingShingle | Alka Verma Amit Goel Priyank Yadav Awale Rupali Bhalchandra Dheeraj Khetan Om P Sanjeev Mallikarjun Gunjiganvi Effect of Covishieldtm (AZD1222) Vaccination on Incidences and Severity of Covid-19 among Health-Care Workers The Indonesian Journal of Occupational Safety and Health abo blood group, coronavirus infection covid-19 critical care intubation mortality severity |
| title | Effect of Covishieldtm (AZD1222) Vaccination on Incidences and Severity of Covid-19 among Health-Care Workers |
| title_full | Effect of Covishieldtm (AZD1222) Vaccination on Incidences and Severity of Covid-19 among Health-Care Workers |
| title_fullStr | Effect of Covishieldtm (AZD1222) Vaccination on Incidences and Severity of Covid-19 among Health-Care Workers |
| title_full_unstemmed | Effect of Covishieldtm (AZD1222) Vaccination on Incidences and Severity of Covid-19 among Health-Care Workers |
| title_short | Effect of Covishieldtm (AZD1222) Vaccination on Incidences and Severity of Covid-19 among Health-Care Workers |
| title_sort | effect of covishieldtm azd1222 vaccination on incidences and severity of covid 19 among health care workers |
| topic | abo blood group, coronavirus infection covid-19 critical care intubation mortality severity |
| url | https://e-journal.unair.ac.id/IJOSH/article/view/45637 |
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