A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer

A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer

Lynch syndrome (LS) is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes. These mutations result in frameshift alterations, leading to the accumulation of errors within microsatellites. Individuals with LS have an elevated risk of developing colorectal an...

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Bibliographic Details
Main Authors: Sneha Pallatt, Sibin Nambidi, Subhamay Adhikary, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Oncology Reviews
Subjects:
endometrial cancer
colorectal cancer
Lynch syndrome
genetic mutations
risk factors
Online Access:https://www.frontiersin.org/articles/10.3389/or.2025.1549416/full
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