A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer
Lynch syndrome (LS) is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes. These mutations result in frameshift alterations, leading to the accumulation of errors within microsatellites. Individuals with LS have an elevated risk of developing colorectal an...
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Frontiers Media S.A.
2025-05-01
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| Series: | Oncology Reviews |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/or.2025.1549416/full |
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| author | Sneha Pallatt Sibin Nambidi Subhamay Adhikary Antara Banerjee Surajit Pathak Asim K. Duttaroy |
| author_facet | Sneha Pallatt Sibin Nambidi Subhamay Adhikary Antara Banerjee Surajit Pathak Asim K. Duttaroy |
| author_sort | Sneha Pallatt |
| collection | DOAJ |
| description | Lynch syndrome (LS) is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes. These mutations result in frameshift alterations, leading to the accumulation of errors within microsatellites. Individuals with LS have an elevated risk of developing colorectal and distant malignancies, including endometrial cancer (EC), which is one of the most common cancer associated with LS. Despite its significance, the association between EC and LS is often underexplored. Given the slow progression of colorectal cancer (CRC), there is an opportunity for early detection and intervention, which can aid in reducing both incidence and mortality through the identification and management of pre-malignant lesions and early-stage tumors in colorectum/endometrium. Recognizing individuals with a heightened risk of CRC is essential for implementing personalized screening strategies. This review summarizes the original research work on LS to find out the correlation of CRC following an endometrial cancer diagnosis in individuals with MMR gene mutations, may involve refine treatment strategies and moreover this review may help clinicians and researchers to get an up-to date information on LS and its advanced treatment possibilities. |
| format | Article |
| id | doaj-art-008bf250d3c142ad9f7a1fcbbd64ff6d |
| institution | DOAJ |
| issn | 1970-5557 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj-art-008bf250d3c142ad9f7a1fcbbd64ff6d2025-08-20T03:09:44ZengFrontiers Media S.A.Oncology Reviews1970-55572025-05-011910.3389/or.2025.15494161549416A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancerSneha Pallatt0Sibin Nambidi1Subhamay Adhikary2Antara Banerjee3Surajit Pathak4Asim K. Duttaroy5Medical Biotechnology Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, IndiaMedical Biotechnology Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, IndiaMedical Biotechnology Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, IndiaMedical Biotechnology Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, IndiaMedical Biotechnology Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, IndiaDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, NorwayLynch syndrome (LS) is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes. These mutations result in frameshift alterations, leading to the accumulation of errors within microsatellites. Individuals with LS have an elevated risk of developing colorectal and distant malignancies, including endometrial cancer (EC), which is one of the most common cancer associated with LS. Despite its significance, the association between EC and LS is often underexplored. Given the slow progression of colorectal cancer (CRC), there is an opportunity for early detection and intervention, which can aid in reducing both incidence and mortality through the identification and management of pre-malignant lesions and early-stage tumors in colorectum/endometrium. Recognizing individuals with a heightened risk of CRC is essential for implementing personalized screening strategies. This review summarizes the original research work on LS to find out the correlation of CRC following an endometrial cancer diagnosis in individuals with MMR gene mutations, may involve refine treatment strategies and moreover this review may help clinicians and researchers to get an up-to date information on LS and its advanced treatment possibilities.https://www.frontiersin.org/articles/10.3389/or.2025.1549416/fullendometrial cancercolorectal cancerLynch syndromegenetic mutationsrisk factors |
| spellingShingle | Sneha Pallatt Sibin Nambidi Subhamay Adhikary Antara Banerjee Surajit Pathak Asim K. Duttaroy A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer Oncology Reviews endometrial cancer colorectal cancer Lynch syndrome genetic mutations risk factors |
| title | A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer |
| title_full | A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer |
| title_fullStr | A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer |
| title_full_unstemmed | A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer |
| title_short | A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer |
| title_sort | brief review of lynch syndrome understanding the dual cancer risk between endometrial and colorectal cancer |
| topic | endometrial cancer colorectal cancer Lynch syndrome genetic mutations risk factors |
| url | https://www.frontiersin.org/articles/10.3389/or.2025.1549416/full |
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