Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives
Abstract As the prevalence of metabolic diseases such as diabetes and obesity continue to rise, the search for more effective and convenient treatments has become a crucial issue in medical research. Microneedles (MNs), as an innovative drug delivery system, have shown advantages in the treatment of...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03432-9 |
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| author | Yao Li Qiu Chen Tingting Wang Zengkai Ji Sagar Regmi Haibin Tong Jian Ju Aifang Wang |
| author_facet | Yao Li Qiu Chen Tingting Wang Zengkai Ji Sagar Regmi Haibin Tong Jian Ju Aifang Wang |
| author_sort | Yao Li |
| collection | DOAJ |
| description | Abstract As the prevalence of metabolic diseases such as diabetes and obesity continue to rise, the search for more effective and convenient treatments has become a crucial issue in medical research. Microneedles (MNs), as an innovative drug delivery system, have shown advantages in the treatment of metabolic diseases in recent years. MNs-based drug delivery system, which use MNs to deliver drugs directly to the subcutaneous tissue, improve drug bioavailability and reduce systemic side effects. This review aims to summarize the latest concepts, designs, and types of MNs, and to investigate the materials and manufacturing methods used in their construction. Subsequently, the mechanisms of drug delivery and graded release of MNs and recent research progress are further summarized. This article focuses on the application of MNs in the treatment of common metabolic diseases, with a special emphasis on the progress and optimization of diabetic and anti-obesity MNs. The main challenges and future perspectives in the production and evaluation of MNs, as well as in enhancing treatment efficacy and improving safety, are elucidated. |
| format | Article |
| id | doaj-art-00895a7ef70144baa1b44eba79e62edc |
| institution | OA Journals |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-00895a7ef70144baa1b44eba79e62edc2025-08-20T02:25:16ZengBMCJournal of Nanobiotechnology1477-31552025-05-0123112510.1186/s12951-025-03432-9Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectivesYao Li0Qiu Chen1Tingting Wang2Zengkai Ji3Sagar Regmi4Haibin Tong5Jian Ju6Aifang Wang7Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou UniversityDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou Institute, University of Chinese Academy of SciencesWenzhou Institute, University of Chinese Academy of SciencesDepartment of Radiation Oncology, University Hospital Seidman Cancer Center ClevelandZhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou UniversityWenzhou Institute, University of Chinese Academy of SciencesThe People’s Hospital of Yuhuan (Yuhuan People’s Hospital Health Community Group)Abstract As the prevalence of metabolic diseases such as diabetes and obesity continue to rise, the search for more effective and convenient treatments has become a crucial issue in medical research. Microneedles (MNs), as an innovative drug delivery system, have shown advantages in the treatment of metabolic diseases in recent years. MNs-based drug delivery system, which use MNs to deliver drugs directly to the subcutaneous tissue, improve drug bioavailability and reduce systemic side effects. This review aims to summarize the latest concepts, designs, and types of MNs, and to investigate the materials and manufacturing methods used in their construction. Subsequently, the mechanisms of drug delivery and graded release of MNs and recent research progress are further summarized. This article focuses on the application of MNs in the treatment of common metabolic diseases, with a special emphasis on the progress and optimization of diabetic and anti-obesity MNs. The main challenges and future perspectives in the production and evaluation of MNs, as well as in enhancing treatment efficacy and improving safety, are elucidated.https://doi.org/10.1186/s12951-025-03432-9MicroneedlesTransdermal drug deliveryMetabolic syndromeDrug carrierMetabolic disease treatmentControlled release |
| spellingShingle | Yao Li Qiu Chen Tingting Wang Zengkai Ji Sagar Regmi Haibin Tong Jian Ju Aifang Wang Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives Journal of Nanobiotechnology Microneedles Transdermal drug delivery Metabolic syndrome Drug carrier Metabolic disease treatment Controlled release |
| title | Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives |
| title_full | Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives |
| title_fullStr | Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives |
| title_full_unstemmed | Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives |
| title_short | Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives |
| title_sort | advances in microneedle based drug delivery system for metabolic diseases structural considerations design strategies and future perspectives |
| topic | Microneedles Transdermal drug delivery Metabolic syndrome Drug carrier Metabolic disease treatment Controlled release |
| url | https://doi.org/10.1186/s12951-025-03432-9 |
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