A Rapid Determination of Cinnarizine in Bulk and Pharmaceutical Dosage Form by LC
A simple, selective, rapid and precise reverse phase high pressure liquid chromatographic method has been developed for the estimation of cinnarizine from pharmaceutical formulation. The method was developed using MICRA-NPS C18 (length×OD×ID =33×8.0×6.0 mm, 1.5 μm) column with a mobile phase consist...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/294096 |
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| author | A. A. Heda A. R. Sonawane G. H. Naranje P. K. Puranik |
| author_facet | A. A. Heda A. R. Sonawane G. H. Naranje P. K. Puranik |
| author_sort | A. A. Heda |
| collection | DOAJ |
| description | A simple, selective, rapid and precise reverse phase high pressure liquid chromatographic method has been developed for the estimation of cinnarizine from pharmaceutical formulation. The method was developed using MICRA-NPS C18 (length×OD×ID =33×8.0×6.0 mm, 1.5 μm) column with a mobile phase consisting of acetonitrile, triethylamine buffer (adjusted to pH 4.5 with 10% w/v potassium hydroxide) and tetrahydrofuran in the ratio 30:66:4 respectively, at a flow rate of 0.5 mL/min. Wavelength was fixed at 253 nm. The developed method was validated for linearity, accuracy, precision, limit of detection and limit of quantitation. The proposed method can be used for the routine estimation of cinnarizine in pharmaceutical dosage form. |
| format | Article |
| id | doaj-art-008546889c4346088d11c1f158a9022b |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-008546889c4346088d11c1f158a9022b2025-02-03T01:07:52ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-01731080108410.1155/2010/294096A Rapid Determination of Cinnarizine in Bulk and Pharmaceutical Dosage Form by LCA. A. Heda0A. R. Sonawane1G. H. Naranje2P. K. Puranik3Department of Pharmaceutics, Government College of Pharmacy, Vedant road, Osmanpura, Aurangabad-431005 (M.S.), IndiaDepartment of Pharmaceutics, Government College of Pharmacy, Vedant road, Osmanpura, Aurangabad-431005 (M.S.), IndiaDepartment of Pharmaceutics, Government College of Pharmacy, Vedant road, Osmanpura, Aurangabad-431005 (M.S.), IndiaDepartment of Pharmaceutics, Government College of Pharmacy, Vedant road, Osmanpura, Aurangabad-431005 (M.S.), IndiaA simple, selective, rapid and precise reverse phase high pressure liquid chromatographic method has been developed for the estimation of cinnarizine from pharmaceutical formulation. The method was developed using MICRA-NPS C18 (length×OD×ID =33×8.0×6.0 mm, 1.5 μm) column with a mobile phase consisting of acetonitrile, triethylamine buffer (adjusted to pH 4.5 with 10% w/v potassium hydroxide) and tetrahydrofuran in the ratio 30:66:4 respectively, at a flow rate of 0.5 mL/min. Wavelength was fixed at 253 nm. The developed method was validated for linearity, accuracy, precision, limit of detection and limit of quantitation. The proposed method can be used for the routine estimation of cinnarizine in pharmaceutical dosage form.http://dx.doi.org/10.1155/2010/294096 |
| spellingShingle | A. A. Heda A. R. Sonawane G. H. Naranje P. K. Puranik A Rapid Determination of Cinnarizine in Bulk and Pharmaceutical Dosage Form by LC E-Journal of Chemistry |
| title | A Rapid Determination of Cinnarizine in Bulk and Pharmaceutical Dosage Form by LC |
| title_full | A Rapid Determination of Cinnarizine in Bulk and Pharmaceutical Dosage Form by LC |
| title_fullStr | A Rapid Determination of Cinnarizine in Bulk and Pharmaceutical Dosage Form by LC |
| title_full_unstemmed | A Rapid Determination of Cinnarizine in Bulk and Pharmaceutical Dosage Form by LC |
| title_short | A Rapid Determination of Cinnarizine in Bulk and Pharmaceutical Dosage Form by LC |
| title_sort | rapid determination of cinnarizine in bulk and pharmaceutical dosage form by lc |
| url | http://dx.doi.org/10.1155/2010/294096 |
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