Sequence characteristics define trade-offs between on-target and genome-wide off-target hybridization of oligoprobes.

Sequence characteristics define trade-offs between on-target and genome-wide off-target hybridization of oligoprobes.

Off-target oligoprobe's interaction with partially complementary nucleotide sequences represents a problem for many bio-techniques. The goal of the study was to identify oligoprobe sequence characteristics that control the ratio between on-target and off-target hybridization. To understand the...

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Bibliographic Details
Main Authors: Olga V Matveeva, Aleksey Y Ogurtsov, Nafisa N Nazipova, Svetlana A Shabalina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0199162&type=printable
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