Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio
The current study was planned to compare serum levels of secreted frizzled related protein-4, insulin resistance and waist-to-height ratio in individuals with and without a diabetic background, and to assess the correlation of these markers with family history of diabetes. The cross-sectional compa...
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Pakistan Medical Association
2024-06-01
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| Series: | Journal of the Pakistan Medical Association |
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| Online Access: | https://jpma.org.pk/index.php/public_html/article/view/10405 |
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| author | Sana Akhlaq Saba Khaliq |
| author_facet | Sana Akhlaq Saba Khaliq |
| author_sort | Sana Akhlaq |
| collection | DOAJ |
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The current study was planned to compare serum levels of secreted frizzled related protein-4, insulin resistance and waist-to-height ratio in individuals with and without a diabetic background, and to assess the correlation of these markers with family history of diabetes. The cross-sectional comparative study comprised 80 subjects with confirmed normal glucose tolerance values. Parameters assessed included secreted frizzled related protein-4, fasting glucose, random glucose, fasting insulin, homeostasis model of assessment of insulin resistance and waist-to-height ratio values. Those without a diabetic background had significantly higher frizzled related protein-4 levels (p=0.02). Although subjects with family history of diabetes showed higher mean fasting glucose, waist circumference and waist-to-height ratio, these differences were not statistically significant (p>0.05). However, there was a strong positive correlation with waist circumference, waist-to-height ratio, fasting insulin and homeostasis model of assessment of insulin resistance (p=0.0001).
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| format | Article |
| id | doaj-art-00638b0749674cee9250e3091e7c705c |
| institution | Kabale University |
| issn | 0030-9982 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj-art-00638b0749674cee9250e3091e7c705c2025-08-20T03:40:01ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822024-06-0174710.47391/JPMA.10405Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratioSana Akhlaq0Saba Khaliq1Department of Physiology, Gujranwala Medical College, Gujranwala, Pakistan.Department of Physiology, Gujranwala Medical College, Gujranwala, Pakistan. The current study was planned to compare serum levels of secreted frizzled related protein-4, insulin resistance and waist-to-height ratio in individuals with and without a diabetic background, and to assess the correlation of these markers with family history of diabetes. The cross-sectional comparative study comprised 80 subjects with confirmed normal glucose tolerance values. Parameters assessed included secreted frizzled related protein-4, fasting glucose, random glucose, fasting insulin, homeostasis model of assessment of insulin resistance and waist-to-height ratio values. Those without a diabetic background had significantly higher frizzled related protein-4 levels (p=0.02). Although subjects with family history of diabetes showed higher mean fasting glucose, waist circumference and waist-to-height ratio, these differences were not statistically significant (p>0.05). However, there was a strong positive correlation with waist circumference, waist-to-height ratio, fasting insulin and homeostasis model of assessment of insulin resistance (p=0.0001). ---Continue https://jpma.org.pk/index.php/public_html/article/view/10405Wnt signalling pathwayFrizzled related protein 4Diabetes mellitusType 2Insulin resistanceWaist-height ratio |
| spellingShingle | Sana Akhlaq Saba Khaliq Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio Journal of the Pakistan Medical Association Wnt signalling pathway Frizzled related protein 4 Diabetes mellitus Type 2 Insulin resistance Waist-height ratio |
| title | Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio |
| title_full | Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio |
| title_fullStr | Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio |
| title_full_unstemmed | Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio |
| title_short | Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio |
| title_sort | normoglycemia and type 2 diabetes exploring secreted frizzled 4 insulin resistance and waist height ratio |
| topic | Wnt signalling pathway Frizzled related protein 4 Diabetes mellitus Type 2 Insulin resistance Waist-height ratio |
| url | https://jpma.org.pk/index.php/public_html/article/view/10405 |
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