Serological survey in a university community after the fourth wave of COVID-19 in Senegal.
A cross-sectional survey was conducted at Polytechnic High School (PHS) to assess the spread of COVID-19 infection among students and staff. A random cluster sampling was conducted between May 19 and August 18, 2022, after the fourth wave of COVID-19 in Senegal. IgM and IgG SARS-CoV-2 antibodies wer...
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Public Library of Science (PLoS)
2024-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0298509 |
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| author | Fatou Thiam Abou Abdallah Malick Diouara Clemence Stephanie Chloe Anoumba Ndiaye Ibrahima Diouf Khadim Kebe Assane Senghor Djibaba Djoumoi Mame Ndew Mbaye Idy Diop Sarbanding Sane Seynabou Coundoul Sophie Deli Tene Mamadou Diop Abdou Lahat Dieng Mamadou Ndiaye Saidou Moustapha Sall Massamba Diouf Cheikh Momar Nguer |
| author_facet | Fatou Thiam Abou Abdallah Malick Diouara Clemence Stephanie Chloe Anoumba Ndiaye Ibrahima Diouf Khadim Kebe Assane Senghor Djibaba Djoumoi Mame Ndew Mbaye Idy Diop Sarbanding Sane Seynabou Coundoul Sophie Deli Tene Mamadou Diop Abdou Lahat Dieng Mamadou Ndiaye Saidou Moustapha Sall Massamba Diouf Cheikh Momar Nguer |
| author_sort | Fatou Thiam |
| collection | DOAJ |
| description | A cross-sectional survey was conducted at Polytechnic High School (PHS) to assess the spread of COVID-19 infection among students and staff. A random cluster sampling was conducted between May 19 and August 18, 2022, after the fourth wave of COVID-19 in Senegal. IgM and IgG SARS-CoV-2 antibodies were screened using WANTAI SARS-CoV-2 ELISA assays. Seroprevalence and descriptive statistics were calculated, and associations between seropositivity and different factors were determined using logistic regression. A total of 637 participants were recruited and the median age was 21 years [18-63]. 62.0% of the participants were female, and 36.89% were male, with a male-to-female ratio = 0.59. The overall IgG and IgM seroprevalence were 92% and 6.91% respectively. Among those who tested positive for IgM, 6.75% were also positive for IgG, and 0.15% were negative for IgG. Interestingly, 6.90% of participants tested negative for both IgM and IgG. We found a higher IgM seroprevalence in men than women (9.4% vs. 5.6%) and a lower IgM seroprevalence in (18-25) age group compared to (55-65) years. We revealed a significant difference according to IgG seroprevalence among participants who declared fatigue symptoms [92.06% (95% CI: 89.96-94.16)] compared to those who did not [80.39% (95% CI: 77.31-83.47)], p = 0.0027. IgM seropositivity was found to be associated with Body Mass Index (BMI) categories (O.R. 0.238, p = 0.043), ethnic group (O.R. 0.723, p = 0.046), and marital status (O.R. 2.399, p = 0.021). Additionally, IgG seropositivity was linked to vaccination status (O.R. 4.741, p < 0.001). Our study found that most students and staff at PHS were exposed to SARS-CoV-2, confirming the virus's circulation at the time of the survey. We also identified differences in individual susceptibility that need further clarification. Our results highlight the importance of seroepidemiological surveys to assess the true impact of the COVID-19 pandemic in a community and to monitor variations in antibody response. |
| format | Article |
| id | doaj-art-0061e17523b740aebe00df5fa6cccdeb |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-0061e17523b740aebe00df5fa6cccdeb2025-08-20T02:22:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011911e029850910.1371/journal.pone.0298509Serological survey in a university community after the fourth wave of COVID-19 in Senegal.Fatou ThiamAbou Abdallah Malick DiouaraClemence Stephanie Chloe Anoumba NdiayeIbrahima DioufKhadim KebeAssane SenghorDjibaba DjoumoiMame Ndew MbayeIdy DiopSarbanding SaneSeynabou CoundoulSophie Deli TeneMamadou DiopAbdou Lahat DiengMamadou NdiayeSaidou Moustapha SallMassamba DioufCheikh Momar NguerA cross-sectional survey was conducted at Polytechnic High School (PHS) to assess the spread of COVID-19 infection among students and staff. A random cluster sampling was conducted between May 19 and August 18, 2022, after the fourth wave of COVID-19 in Senegal. IgM and IgG SARS-CoV-2 antibodies were screened using WANTAI SARS-CoV-2 ELISA assays. Seroprevalence and descriptive statistics were calculated, and associations between seropositivity and different factors were determined using logistic regression. A total of 637 participants were recruited and the median age was 21 years [18-63]. 62.0% of the participants were female, and 36.89% were male, with a male-to-female ratio = 0.59. The overall IgG and IgM seroprevalence were 92% and 6.91% respectively. Among those who tested positive for IgM, 6.75% were also positive for IgG, and 0.15% were negative for IgG. Interestingly, 6.90% of participants tested negative for both IgM and IgG. We found a higher IgM seroprevalence in men than women (9.4% vs. 5.6%) and a lower IgM seroprevalence in (18-25) age group compared to (55-65) years. We revealed a significant difference according to IgG seroprevalence among participants who declared fatigue symptoms [92.06% (95% CI: 89.96-94.16)] compared to those who did not [80.39% (95% CI: 77.31-83.47)], p = 0.0027. IgM seropositivity was found to be associated with Body Mass Index (BMI) categories (O.R. 0.238, p = 0.043), ethnic group (O.R. 0.723, p = 0.046), and marital status (O.R. 2.399, p = 0.021). Additionally, IgG seropositivity was linked to vaccination status (O.R. 4.741, p < 0.001). Our study found that most students and staff at PHS were exposed to SARS-CoV-2, confirming the virus's circulation at the time of the survey. We also identified differences in individual susceptibility that need further clarification. Our results highlight the importance of seroepidemiological surveys to assess the true impact of the COVID-19 pandemic in a community and to monitor variations in antibody response.https://doi.org/10.1371/journal.pone.0298509 |
| spellingShingle | Fatou Thiam Abou Abdallah Malick Diouara Clemence Stephanie Chloe Anoumba Ndiaye Ibrahima Diouf Khadim Kebe Assane Senghor Djibaba Djoumoi Mame Ndew Mbaye Idy Diop Sarbanding Sane Seynabou Coundoul Sophie Deli Tene Mamadou Diop Abdou Lahat Dieng Mamadou Ndiaye Saidou Moustapha Sall Massamba Diouf Cheikh Momar Nguer Serological survey in a university community after the fourth wave of COVID-19 in Senegal. PLoS ONE |
| title | Serological survey in a university community after the fourth wave of COVID-19 in Senegal. |
| title_full | Serological survey in a university community after the fourth wave of COVID-19 in Senegal. |
| title_fullStr | Serological survey in a university community after the fourth wave of COVID-19 in Senegal. |
| title_full_unstemmed | Serological survey in a university community after the fourth wave of COVID-19 in Senegal. |
| title_short | Serological survey in a university community after the fourth wave of COVID-19 in Senegal. |
| title_sort | serological survey in a university community after the fourth wave of covid 19 in senegal |
| url | https://doi.org/10.1371/journal.pone.0298509 |
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