Subclinical cardiac dysfunction detected by speckle-tracking echocardiography in patients with liver cirrhosis undergoing liver transplantation
Abstract Background Cirrhosis is associated with chronic cardiovascular dysfunction termed cirrhotic cardiomyopathy (CCM), characterized by myocardial hypertrophy and diastolic dysfunction. Detecting early cardiac changes is crucial, especially in patients undergoing liver transplantation. Objective...
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SpringerOpen
2024-12-01
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| Series: | Egyptian Liver Journal |
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| Online Access: | https://doi.org/10.1186/s43066-024-00397-6 |
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| author | Nguyen Tai Thu Pham Dang Hai Nguyen Thi Kieu Ly Pham Nguyen Son Nguyen Huu Thanh Dang Hoang Thien |
| author_facet | Nguyen Tai Thu Pham Dang Hai Nguyen Thi Kieu Ly Pham Nguyen Son Nguyen Huu Thanh Dang Hoang Thien |
| author_sort | Nguyen Tai Thu |
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| description | Abstract Background Cirrhosis is associated with chronic cardiovascular dysfunction termed cirrhotic cardiomyopathy (CCM), characterized by myocardial hypertrophy and diastolic dysfunction. Detecting early cardiac changes is crucial, especially in patients undergoing liver transplantation. Objective: This study aims to evaluate left ventricular systolic function in cirrhotic patients undergoing liver transplantation using speckle-tracking echocardiography. Methods A prospective observational study was conducted involving 54 cirrhotic patients who underwent liver transplantation, along with 28 age- and sex-matched healthy controls. Echocardiography, including conventional and two-dimensional speckle tracking echocardiography (2D-STE), was performed at baseline and one-month post-transplantation. Results The mean age in the cirrhotic group was 52.2 ± 12.7 years, with no significant difference compared to the control group. Viral hepatitis was the predominant etiology of cirrhosis (68.6%). Conventional echocardiography did not reveal significant differences between groups in LV ejection fraction [62% (56–69) vs. 59% (56–62); p = 0.830]. However, in cirrhotic patients, 2D-STE demonstrated significantly lower LV global longitudinal strain (LV-GLS) [17.5 (15.5–19.1) vs 19.0 (18.0–19.7), p = 0.006]. Post-transplantation, conventional echocardiography indices remained unchanged, while 2D-STE showed remarkable improvement in LV function, with increased LV-GLS compared to pre-transplantation value. Conclusions 2D-STE is a valuable tool for detecting and monitoring left ventricular systolic dysfunction in liver cirrhosis patients, particularly following transplantation. While conventional echocardiography may not detect subtle changes, 2D-STE reveals improvements in LV function post-transplantation, emphasizing its role in assessing cirrhotic cardiomyopathy. |
| format | Article |
| id | doaj-art-0061591209694571a178d4e958df909e |
| institution | OA Journals |
| issn | 2090-6226 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SpringerOpen |
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| series | Egyptian Liver Journal |
| spelling | doaj-art-0061591209694571a178d4e958df909e2025-08-20T02:20:41ZengSpringerOpenEgyptian Liver Journal2090-62262024-12-011411710.1186/s43066-024-00397-6Subclinical cardiac dysfunction detected by speckle-tracking echocardiography in patients with liver cirrhosis undergoing liver transplantationNguyen Tai Thu0Pham Dang Hai1Nguyen Thi Kieu Ly2Pham Nguyen Son3Nguyen Huu Thanh4Dang Hoang Thien5Intensive Care Unit, 108 Military Central HospitalIntensive Care Unit, 108 Military Central HospitalDepartment of Cardiology, 108 Military Central HospitalDepartment of Cardiology, 108 Military Central HospitalCollege of Health Sciences, VinUniversityCollege of Health Sciences, VinUniversityAbstract Background Cirrhosis is associated with chronic cardiovascular dysfunction termed cirrhotic cardiomyopathy (CCM), characterized by myocardial hypertrophy and diastolic dysfunction. Detecting early cardiac changes is crucial, especially in patients undergoing liver transplantation. Objective: This study aims to evaluate left ventricular systolic function in cirrhotic patients undergoing liver transplantation using speckle-tracking echocardiography. Methods A prospective observational study was conducted involving 54 cirrhotic patients who underwent liver transplantation, along with 28 age- and sex-matched healthy controls. Echocardiography, including conventional and two-dimensional speckle tracking echocardiography (2D-STE), was performed at baseline and one-month post-transplantation. Results The mean age in the cirrhotic group was 52.2 ± 12.7 years, with no significant difference compared to the control group. Viral hepatitis was the predominant etiology of cirrhosis (68.6%). Conventional echocardiography did not reveal significant differences between groups in LV ejection fraction [62% (56–69) vs. 59% (56–62); p = 0.830]. However, in cirrhotic patients, 2D-STE demonstrated significantly lower LV global longitudinal strain (LV-GLS) [17.5 (15.5–19.1) vs 19.0 (18.0–19.7), p = 0.006]. Post-transplantation, conventional echocardiography indices remained unchanged, while 2D-STE showed remarkable improvement in LV function, with increased LV-GLS compared to pre-transplantation value. Conclusions 2D-STE is a valuable tool for detecting and monitoring left ventricular systolic dysfunction in liver cirrhosis patients, particularly following transplantation. While conventional echocardiography may not detect subtle changes, 2D-STE reveals improvements in LV function post-transplantation, emphasizing its role in assessing cirrhotic cardiomyopathy.https://doi.org/10.1186/s43066-024-00397-6Cirrhotic cardiomyopathy (CCM)Liver cirrhosisLiver transplantationTwo-dimensional speckle-tracking echocardiography (2D-STE)Left ventricular function |
| spellingShingle | Nguyen Tai Thu Pham Dang Hai Nguyen Thi Kieu Ly Pham Nguyen Son Nguyen Huu Thanh Dang Hoang Thien Subclinical cardiac dysfunction detected by speckle-tracking echocardiography in patients with liver cirrhosis undergoing liver transplantation Egyptian Liver Journal Cirrhotic cardiomyopathy (CCM) Liver cirrhosis Liver transplantation Two-dimensional speckle-tracking echocardiography (2D-STE) Left ventricular function |
| title | Subclinical cardiac dysfunction detected by speckle-tracking echocardiography in patients with liver cirrhosis undergoing liver transplantation |
| title_full | Subclinical cardiac dysfunction detected by speckle-tracking echocardiography in patients with liver cirrhosis undergoing liver transplantation |
| title_fullStr | Subclinical cardiac dysfunction detected by speckle-tracking echocardiography in patients with liver cirrhosis undergoing liver transplantation |
| title_full_unstemmed | Subclinical cardiac dysfunction detected by speckle-tracking echocardiography in patients with liver cirrhosis undergoing liver transplantation |
| title_short | Subclinical cardiac dysfunction detected by speckle-tracking echocardiography in patients with liver cirrhosis undergoing liver transplantation |
| title_sort | subclinical cardiac dysfunction detected by speckle tracking echocardiography in patients with liver cirrhosis undergoing liver transplantation |
| topic | Cirrhotic cardiomyopathy (CCM) Liver cirrhosis Liver transplantation Two-dimensional speckle-tracking echocardiography (2D-STE) Left ventricular function |
| url | https://doi.org/10.1186/s43066-024-00397-6 |
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