The Adenosinergic System in Diabetic Retinopathy
The neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/4270301 |
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| _version_ | 1832554471108902912 |
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| author | J. Vindeirinho A. R. Santiago C. Cavadas A. F. Ambrósio P. F. Santos |
| author_facet | J. Vindeirinho A. R. Santiago C. Cavadas A. F. Ambrósio P. F. Santos |
| author_sort | J. Vindeirinho |
| collection | DOAJ |
| description | The neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four types of adenosine receptors (A1R, A2AR, A2BR, and A3R), and thus could be revealed as a potential player in the events unfolding in the early stages of diabetic retinopathy. Herein, we review the studies that explore the impact of diabetic conditions on the retinal adenosinergic system, as well as the role of the said system in ameliorating or exacerbating those conditions. The experimental results described suggest that this system is heavily affected by diabetic conditions and that the modulation of its components could reveal potential therapeutic targets for the treatment of diabetic retinopathy, particularly in the early stages of the disease. |
| format | Article |
| id | doaj-art-005e00bd8a4441248ca829babd100b1f |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-005e00bd8a4441248ca829babd100b1f2025-02-03T05:51:20ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/42703014270301The Adenosinergic System in Diabetic RetinopathyJ. Vindeirinho0A. R. Santiago1C. Cavadas2A. F. Ambrósio3P. F. Santos4Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, PortugalCNC.IBILI, University of Coimbra, 3004-504 Coimbra, PortugalCenter for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, PortugalCNC.IBILI, University of Coimbra, 3004-504 Coimbra, PortugalCNC.IBILI, University of Coimbra, 3004-504 Coimbra, PortugalThe neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four types of adenosine receptors (A1R, A2AR, A2BR, and A3R), and thus could be revealed as a potential player in the events unfolding in the early stages of diabetic retinopathy. Herein, we review the studies that explore the impact of diabetic conditions on the retinal adenosinergic system, as well as the role of the said system in ameliorating or exacerbating those conditions. The experimental results described suggest that this system is heavily affected by diabetic conditions and that the modulation of its components could reveal potential therapeutic targets for the treatment of diabetic retinopathy, particularly in the early stages of the disease.http://dx.doi.org/10.1155/2016/4270301 |
| spellingShingle | J. Vindeirinho A. R. Santiago C. Cavadas A. F. Ambrósio P. F. Santos The Adenosinergic System in Diabetic Retinopathy Journal of Diabetes Research |
| title | The Adenosinergic System in Diabetic Retinopathy |
| title_full | The Adenosinergic System in Diabetic Retinopathy |
| title_fullStr | The Adenosinergic System in Diabetic Retinopathy |
| title_full_unstemmed | The Adenosinergic System in Diabetic Retinopathy |
| title_short | The Adenosinergic System in Diabetic Retinopathy |
| title_sort | adenosinergic system in diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2016/4270301 |
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